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World J Gastroenterol. Apr 28, 2014; 20(16): 4607-4617
Published online Apr 28, 2014. doi: 10.3748/wjg.v20.i16.4607
Published online Apr 28, 2014. doi: 10.3748/wjg.v20.i16.4607
Helicobacter pylori infection and diabetes: Is it a myth or fact?
Cong He, Zhen Yang, Nong-Hua Lu, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Author contributions: He C, Yang Z and Lu NH contributed equally to the review and writing of this paper.
Supported by The National Natural Science Foundation of China, No. 81060038 and No. 81270479, and grants from Jiangxi Province Talent 555 Project, and the National Science and Technology Major Projects for “Major New Drugs Innovation and Development” of China, No. 2011ZX09302-007-03
Correspondence to: Nong-Hua Lu, MD, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang 330006, Jiangxi Province, China. lunonghua@ncu.edu.cn
Telephone: +86-791-88692705 Fax: +86-791-88623153
Received: November 27, 2013
Revised: February 10, 2014
Accepted: March 6, 2014
Published online: April 28, 2014
Revised: February 10, 2014
Accepted: March 6, 2014
Published online: April 28, 2014
Core Tip
Core tip: A growing body of evidence suggests that Helicobacter pylori (H. pylori) infection is associated with diabetes, and may cause insulin resistance and chronic inflammation that contribute to the disease. H. pylori-induced gastritis can also potentially affect the secretion of gastric-related hormones and inflammatory cytokines. However, the relationship between H. pylori infection and diabetes is still under debate and further studies are warranted to define their association in more detail, and to characterize the corresponding mechanisms and mediators.