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World J Gastroenterol. Apr 14, 2014; 20(14): 3889-3904
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3889
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3889
Extent of lymphadenectomy and perioperative therapies: Two open issues in gastric cancer
Andrea Giuliani, Michelangelo Miccini, Luigi Basso, Department of Surgery “Pietro Valdoni”, “Sapienza” University of Rome, Medical School, Policlinico “Umberto I”, 00161 Rome, Italy
Author contributions: Giuliani A, Miccini M and Basso L contributed equally to this work.
Correspondence to: Luigi Basso, Professor, Department of Surgery “PietroValdoni”, “Sapienza” University of Rome, Medical School, Policlinico “Umberto I”, viale del Policlinico 155, 00161 Rome, Italy. luigi.basso@uniroma1.it
Telephone: +39-6-49972167 Fax: +39-6-49977260
Received: October 23, 2013
Revised: November 23, 2013
Accepted: March 5, 2014
Published online: April 14, 2014
Revised: November 23, 2013
Accepted: March 5, 2014
Published online: April 14, 2014
Core Tip
Core tip: The authors in this review present an update on treatment of gastric cancer in relation to the role of extent of lymphadenectomy and of new nonoperative strategies, to employ preoperatively, intraoperatively, and postoperatively. The above therapeutical options are assessed by reviewing the most authoritative, large, and referenced randomised controlled trials and meta-analyses published in the English literature.