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World J Gastroenterol. Apr 14, 2014; 20(14): 3889-3904
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3889
Extent of lymphadenectomy and perioperative therapies: Two open issues in gastric cancer
Andrea Giuliani, Michelangelo Miccini, Luigi Basso
Andrea Giuliani, Michelangelo Miccini, Luigi Basso, Department of Surgery “Pietro Valdoni”, “Sapienza” University of Rome, Medical School, Policlinico “Umberto I”, 00161 Rome, Italy
Author contributions: Giuliani A, Miccini M and Basso L contributed equally to this work.
Correspondence to: Luigi Basso, Professor, Department of Surgery “PietroValdoni”, “Sapienza” University of Rome, Medical School, Policlinico “Umberto I”, viale del Policlinico 155, 00161 Rome, Italy. luigi.basso@uniroma1.it
Telephone: +39-6-49972167 Fax: +39-6-49977260
Received: October 23, 2013
Revised: November 23, 2013
Accepted: March 5, 2014
Published online: April 14, 2014
Processing time: 172 Days and 17.6 Hours
Abstract

Gastric cancer is one of the leading causes of death for cancer worldwide, although geographical variations in incidence exist. Over the last decades, its incidence and mortality have gradually decreased in Western countries, while these have increased, or remained stable, in the other world regions. Gastric cancer is often diagnosed at an advanced stage, with the only notable exception of Japan, where nationwide screening programs are enforced, due to local high incidence. Curative- intent surgery (i.e., gastrectomy, total or partial, and lymphadenectomy) remains the cornerstone of treatment of gastric cancer. Much has been debated about the extent of lymph node dissection and, although it is a valuable contribution to staging and cure, operative treatment only represents one aspect of overall effective management, as the risk of both locoregional and distant recurrences are high, and bear a poor prognosis. As a matter of fact, surgery, as a single modality treatment, has probably achieved its maximum efficacy for local control and survival, while other accompanying nonsurgical treatment modalities have to be taken into account, although their role is still the subject of considerable debate. The authors in this review present an update on the outcome of treatment of gastric cancer in relation to the extent of lymphadenectomy and of various nonsurgical preoperative, intraoperative, and postoperative strategies.

Keywords: Gastric cancer; Adenocarcinoma; Postoperative; Preoperative; Chemoradiotherapy; Chemotherapy; Radiotherapy; Intraperitoneal; Randomized controlled trial; Meta-analysis

Core tip: The authors in this review present an update on treatment of gastric cancer in relation to the role of extent of lymphadenectomy and of new nonoperative strategies, to employ preoperatively, intraoperatively, and postoperatively. The above therapeutical options are assessed by reviewing the most authoritative, large, and referenced randomised controlled trials and meta-analyses published in the English literature.