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World J Gastroenterol. Oct 28, 2013; 19(40): 6902-6910
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6902
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6902
Diabetes mellitus carries a risk of gastric cancer: A meta-analysis
Shouji Shimoyama, Gastrointestinal Unit, Settlement Clinic, Tokyo 120-0003, Japan
Author contributions: Shimoyama S solely contributed to this paper.
Correspondence to: Shouji Shimoyama, MD, Gastrointestinal Unit, Settlement Clinic, 4-20-7, Towa, Adachi-ku, Tokyo 120-0003, Japan. shimoyama@apost.plala.or.jp
Telephone: +81-3-36057747 Fax: +81-3-36050244
Received: May 14, 2013
Revised: June 27, 2013
Accepted: July 30, 2013
Published online: October 28, 2013
Processing time: 212 Days and 21.2 Hours
Revised: June 27, 2013
Accepted: July 30, 2013
Published online: October 28, 2013
Processing time: 212 Days and 21.2 Hours
Core Tip
Core tip: Diabetes mellitus (DM) was significantly associated with gastric cancer (GC) with a risk ratio of 1.41. This positive DM-GC association was also observed in both sexes with a greater magnitude of risk in females than male, and in East Asian patients but not in Western patients. This study could provide one answer to current inconsistent knowledge across trials concerning a positive/inverse DM-GC association. Since DM patients are less likely to be screened for cancers, clinicians caring for DM patients should remain alert to detect GC especially in females, since there are fewer female than male GC patients in the general population.