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©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Oct 28, 2013; 19(40): 6863-6868
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6863
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6863
Estrogen improves the hyperdynamic circulation and hyporeactivity of mesenteric arteries by alleviating oxidative stress in partial portal vein ligated rats
Bin Zhang, Cheng-Gang Zhang, Quan-Bo Zhou, Wei Chen, Zhi-Yong Wu, Department of General Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Author contributions: Zhang B, Chen W and Wu ZY designed research; Zhang B, Zhang CG and Zhou QB performed research; Zhang B and Zhang CG analyzed data; Zhang B and Zhou QB co-wrote the paper.
Correspondence to: Zhi-Yong Wu, MD, PhD, Department of General Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 1630 Dongfang Road, Shanghai 200127, China. zhiyongwu@gmail.com
Telephone: +86-21-68383732 Fax: +86-21-68383090
Received: June 29, 2013
Revised: August 18, 2013
Accepted: September 4, 2013
Published online: October 28, 2013
Processing time: 136 Days and 19 Hours
Revised: August 18, 2013
Accepted: September 4, 2013
Published online: October 28, 2013
Processing time: 136 Days and 19 Hours
Core Tip
Core tip: Vascular hyporeactivity is affected by gender and estrogen. The aim of the present study was to investigate whether estrogen could attenuate the severity of hyperdynamic circulation and the underlying mechanism in pre-hepatic portal hypertensive rats without cirrhosis, with a focus on oxidative stress. The authors proposed that treatment with estrogen could improve the systemic and splanchnic hyperdynamic circulation in partial portal vein ligation rats, in part due to the alleviation of oxidative stress.