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World J Gastroenterol. Oct 28, 2013; 19(40): 6794-6804
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6794
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6794
Gut-lung crosstalk in pulmonary involvement with inflammatory bowel diseases
Hui Wang, Jing-Shi Liu, Shao-Hua Peng, Xi-Yun Deng, De-Mao Zhu, Sara Javidiparsijani, Gui-Rong Wang, Dai-Qiang Li, Long-Xuan Li, Yi-Chun Wang, Jun-Ming Luo, Department of Radiation Oncology, the Affiliated Hunan Provincial Tumor Hospital, Xiangya Medical School, Central South University, Changsha 410013, Hunan Province, China
Jun-Ming Luo, Department of Pathology, Qinghai Provincial People's Hospital, Xining 810007, Qinghai Province, China
Jing-Shi Liu, Yi-Chun Wang, Department of Anesthesiology, the Affiliated Hunan Provincial Tumor Hospital at Central South University, Changsha 410013, Hunan Province, China
Shao-Hua Peng, Xi-Yun Deng, Department of Pathology, Medical College of Hunan Normal University, Changsha 410013, Hunan Province, China
De-Mao Zhu, Department of Pathology, Changsha Central Hospital, Changsha 410007, Hunan Province, China
Sara Javidiparsijani, Gui-Rong Wang, Department of Surgery, SUNY Upstate Medical University, Syracuse, NY 13210, United States
Dai-Qiang Li, Department of Pathology, the Second Affiliated Hospital, Xiangya Medical School, Central South University, Changsha 410013, Hunan Province, China
Long-Xuan Li, Department of Neurology, Guangdong Medical College Affiliated Hospital, Zhanjiang 524001, Guangdong Province, China
Author contributions: Wang H, Liu JS and Peng SH contributed equally to this work; Luo JM, Wang H, Liu JS, Peng SH, Zhu DM, Deng XY and Wang YC designed the study; Luo JM Wang H, Liu JS and Li LX analyzed data; Luo JM, Wang H and Liu JS wrote the paper; Li DQ, Javidiparsijani S and Wang GR revised the paper and provided important suggestions; all authors have read and approved the final manuscript.
Correspondence to: Jun-Ming Luo, MD, Professor of Pathology, Department of Pathology, Qinghai Provincial People's Hospital, 2 Gonghe Road, Xining 810007, Qinghai Province, China. jluo099@163.com
Telephone: +86-731-89762696 Fax: +86-731-88651999
Received: May 31, 2013
Revised: July 22, 2013
Accepted: September 4, 2013
Published online: October 28, 2013
Processing time: 165 Days and 17.1 Hours
Revised: July 22, 2013
Accepted: September 4, 2013
Published online: October 28, 2013
Processing time: 165 Days and 17.1 Hours
Core Tip
Core tip: According to traditional Chinese medicine, the lung and the intestine are a pair of related organ systems (Biao-Li). The lung has no anatomical connection with the main inflammatory site of the bowel. Why does the inflammatory process shift from the gastrointestinal tract to the airways? We hypothesize that each individual cell or molecule not only plays its local role in its own organ, but also plays a “social” role to contribute distal communication through the epithelia. Inflammatory bowel disease may be a good example to study crosstalk between the gut and the lungs.