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World J Gastroenterol. Oct 21, 2013; 19(39): 6618-6624
Published online Oct 21, 2013. doi: 10.3748/wjg.v19.i39.6618
Published online Oct 21, 2013. doi: 10.3748/wjg.v19.i39.6618
Anisodamine accelerates spontaneous passage of single symptomatic bile duct stones ≤ 10 mm
Jun Gao, Xue-Mei Ding, Shan Ke, Wen-Bing Sun, Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100043, China
Yi-Ming Zhou, Xiao-Jun Qian, Department of Radiology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100043, China
Rui-Liang Ma, Department of General Surgery, 254 Hospital of PLA, Tianjin 300142, China
Chun-Min Ning, Department of General Surgery, Chaoyang Central Hospital, Chaoyang 122000, Liaoning Province, China
Zong-Hai Xin, Department of General Surgery, Zhanhua People’s Hospital, Zhanhua 256800, Shandong Province, China
Author contributions: Gao J and Sun WB designed the study; Ke S, Ma RL, Ning CM and Xin ZH collected the data; Zhou YM and Qian XJ analyzed the radiological results; Ding XM and Ke S performed the literature search and analyzed the data; Gao J and Sun WB wrote the paper.
Correspondence to: Wen-Bing Sun, MD, Professor, Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital Affiliated to Capital Medical University, No. 5 Jingyuan Street, Beijing 100043, China. cyhswb@qq.com
Telephone: +86-10-51718372 Fax: +86-10-51718017
Received: July 11, 2013
Revised: August 12, 2013
Accepted: September 4, 2013
Published online: October 21, 2013
Revised: August 12, 2013
Accepted: September 4, 2013
Published online: October 21, 2013
Core Tip
Core tip: Common bile duct (CBD) stones are known to pass spontaneously in many patients. This phenomenon has not been given sufficient emphasis in terms of optimizing the timing of management of CBD stones. We investigated the rate of spontaneous passage of single and symptomatic CBD stones ≤ 10 mm in diameter in 4 wk with or without a 2-wk course of anisodamine in a multicenter, randomized, placebo-controlled trial. Anisodamine administration for 2 wk can safely accelerate spontaneous passage of single and symptomatic CBD stones ≤ 10 mm in diameter, especially for stones < 5 mm.