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©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Oct 21, 2013; 19(39): 6559-6567
Published online Oct 21, 2013. doi: 10.3748/wjg.v19.i39.6559
Published online Oct 21, 2013. doi: 10.3748/wjg.v19.i39.6559
Effects of integrin-targeted photodynamic therapy on pancreatic carcinoma cell
Min Zhou, Qian-Wen Ni, Shan-Ying Yang, Chun-Ying Qu, Lei-Ming Xu, Digestive Endoscopic Diagnosis and Treatment Center, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China
Min Zhou, Qian-Wen Ni, Shan-Ying Yang, Chun-Ying Qu, Lei-Ming Xu, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China
Peng-Cheng Zhao, Jian-Cheng Zhang, School of Materials Science and Engneering, Shanghai University, Shanghai 200072, China
Author contributions: Zhou M, Ni QW and Xu LM performed the majority of experiments; Xu LM designed the experiments; Yang SY, Zhao PC and Zhang JC provide vital reagents and analytical tools; Zhou M and Qu CY analyzed data; and Zhou M, Ni QW and Xu LM wrote the paper.
Supported by Grants from Shanghai Municipal Health Bureau principal project No. 210009 to Xu LM; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, No. 11DZ2260500
Correspondence to: Dr. Lei-Ming Xu, Chief Physician, Digestive Endoscopic Diagnosis and Treatment Center, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China. leiming.xu@aliyun.com
Telephone: +86-21-25077120 Fax: +86-21-25077120
Received: July 9, 2013
Revised: August 4, 2013
Accepted: August 20, 2013
Published online: October 21, 2013
Processing time: 121 Days and 15.7 Hours
Revised: August 4, 2013
Accepted: August 20, 2013
Published online: October 21, 2013
Processing time: 121 Days and 15.7 Hours
Core Tip
Core tip: Arginine-glycine-aspartic acid (RGD), sequence of small peptide, is an integrin antagonist. Quantum dots are characterized by conjugation with antibodies, peptides, or small molecules. Therefore, the construction of RGD-coupled quantum dots fluorescence probe allows for successful combination to integrin. Photodynamic therapy with a quantum dots-RGD probe, as a photosensitizer, significantly inhibits cell proliferation and increases apoptosis in SW1990 cells.