Review
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World J Gastroenterol. Oct 21, 2013; 19(39): 6540-6547
Published online Oct 21, 2013. doi: 10.3748/wjg.v19.i39.6540
Concepts of oxidative stress and antioxidant defense in Crohn’s disease
Mohammed A Alzoghaibi
Mohammed A Alzoghaibi, Department of Physiology, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia
Author contributions: Alzoghaibi MA designed and performed the research, analyzed the data, and wrote the paper and revised it.
Correspondence to: Mohammed A Alzoghaibi, PhD, Department of Physiology, College of Medicine, King Saud University, Amr Ibn Al As, PO Box 2925, Riyadh 11461, Saudi Arabia. zzoghaibi@gmail.com
Telephone: +96-650-6338400 Fax: +96-611-4672567
Received: May 15, 2013
Revised: August 6, 2013
Accepted: August 12, 2013
Published online: October 21, 2013
Processing time: 177 Days and 0.7 Hours
Core Tip

Core tip: Crohn’s disease is associated with an imbalance, comprising increased reactive oxygen species (ROS) and decreased net antioxidant activity. A deficiency in antioxidant molecules could lead to increased levels of lipid peroxides or ROS, which could act locally or be secreted into the circulation to produce different systemic effects in the patient. Future research should address the question of whether ROS are involved in increasing the production of the different extracellular proteins by enhancing the transcriptions of certain genes using specific transcription factors.