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World J Gastroenterol. Sep 28, 2013; 19(36): 6055-6061
Published online Sep 28, 2013. doi: 10.3748/wjg.v19.i36.6055
Published online Sep 28, 2013. doi: 10.3748/wjg.v19.i36.6055
Liver metastasis is the only independent prognostic factor in AFP-producing gastric cancer
Shoji Hirajima, Shuhei Komatsu, Daisuke Ichikawa, Takeshi Kubota, Kazuma Okamoto, Atsushi Shiozaki, Hitoshi Fujiwara, Hirotaka Konishi, Hisashi Ikoma, Eigo Otsuji, Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
Author contributions: Hirajima S and Komatsu S contributed equally to this work; Hirajima S, Komatsu S and Ichikawa D designed the research; Hirajima S, Komatsu S, Ichikawa D, Kubota T, Okamoto K, Shiozaki A, Fujiwara H, Konishi H, Ikoma H and Otsuji E performed the research; Hirajima S and Komatsu S analyzed the data and wrote the manuscript.
Correspondence to: Shuhei Komatsu, MD, Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachihirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. skomatsu@koto.kpu-m.ac.jp
Telephone: +81-75-2515527 Fax: +81-75-2515522
Received: May 7, 2013
Revised: July 20, 2013
Accepted: August 8, 2013
Published online: September 28, 2013
Processing time: 143 Days and 6.1 Hours
Revised: July 20, 2013
Accepted: August 8, 2013
Published online: September 28, 2013
Processing time: 143 Days and 6.1 Hours
Core Tip
Core tip: In the present study, we re-evaluated the clinicopathological characteristics and clinical outcomes of consecutive patients with α-fetoprotein (AFP)-producing gastric cancer (GC). The results obtained clearly demonstrated that clinical behaviors were different between patients with and without AFP-producing GC. However, the prognosis according to the presence or absence of liver metastasis was similar between patients with and without AFP-producing GC. Our results show that liver metastasis should be specifically targeted in an effort to improve the prognosis of AFP-producing GC.