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World J Gastroenterol. Sep 28, 2013; 19(36): 6011-6019
Published online Sep 28, 2013. doi: 10.3748/wjg.v19.i36.6011
Published online Sep 28, 2013. doi: 10.3748/wjg.v19.i36.6011
Radiofrequency ablation for early oesophageal squamous neoplasia: Outcomes form United Kingdom registry
Rehan J Haidry, Mohammed A Butt, Laurence B Lovat, Department of Surgery and Interventional Science, National Medical Laser Centre, UCL, London W1W 7EJ, United Kingdom
Rehan J Haidry, Mohammed A Butt, Matthew Banks, Abhinav Gupta, Marco Novelli, Laurence B Lovat, Department Gastroenterology, University College Hospital NHS Foundation Trust, London NW1 2BU, United Kingdom
Jason Dunn, Department Gastroenterology, Guy’s and St Thomas’ Hospitals NHS Trust, London SE1 9RT, United Kingdom
Jason Dunn, Institute for Medical Informatics, Oslo University Hospital, 0313 Oslo, Norway
Howard Smart, Department Gastroenterology, Royal Liverpool University Hospital, Merseyside, Liverpool L7 8XP, United Kingdom
Pradeep Bhandari, Department Gastroenterology, Princess Alexandra Hospital, Cosham, Portsmouth PO6 3LY, United Kingdom
Lesley Ann Smith, Department Gastroenterology, Bradford Royal Infirmary, Bradford, West Yorkshire BD9 6RJ, United Kingdom
Robert Willert, Department Gastroenterology, Central Manchester University Hospital, Manchester M13 9WL, United Kingdom
Grant Fullarton, Morris John, Department Gastroenterology, Glasgow Royal Infirmary, Glasgow City G4 0SF, United Kingdom
Massimo Di Pietro, Department Gastroenterology, Addenbrooke’s Hospital, Cambridge CB2 0QQ, United Kingdom
Ian Penman, Royal Infirmary Edinburgh, Edinburgh EH16 4SA, United Kingdom
Author contributions: Haidry RJ, Lovat LB and Dunn J were involved in the study concept and design; Haidry R and Gupta A were involved in statistical analysis and interpretation of data; Haidry R and Lovat LB were involved in drafting of the manuscript; all authors were involved in the acquisition of data.
Supported by The CRUK UCL Early Cancer Medicine Centre; BARRX Medical Inc Grant Supported to Lovat LB; and Covidien plc to support research infrastructure
Correspondence to: Dr. Laurence B Lovat, Consultant Gastroenterologist, Reader in Laser Medicine, Department of Surgery and Interventional Science, National Medical Laser Centre, UCL, 67-73 Riding House Street, London W1W 7EJ, United Kingdom. l.lovat@uclh.nhs.uk
Telephone: +44-20-76799060 Fax: +44-20-78132828
Received: May 4, 2013
Revised: July 17, 2013
Accepted: July 23, 2013
Published online: September 28, 2013
Processing time: 144 Days and 20.5 Hours
Revised: July 17, 2013
Accepted: July 23, 2013
Published online: September 28, 2013
Processing time: 144 Days and 20.5 Hours
Core Tip
Core tip: Squamous cell cancer of the esophagus is an aggressive pathology with a poor prognosis and therefore early intervention is paramount to improve survival. Minimally invasive endoscopic therapy with endoscopic resection and radiofrequency ablation in patients with early squamous neoplasia of the esophagus has the potential to treat selected patients. Early response to RFA is prognostically important. Further studies with more patient numbers are required to explore the long and short term efficacy of this intervention in these complex patients.