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World J Gastroenterol. Sep 28, 2013; 19(36): 5988-5999
Published online Sep 28, 2013. doi: 10.3748/wjg.v19.i36.5988
Published online Sep 28, 2013. doi: 10.3748/wjg.v19.i36.5988
Electroacupuncture improves gut barrier dysfunction in prolonged hemorrhagic shock rats through vagus anti-inflammatory mechanism
Ming-Hua Du, Hong-Min Luo, Sen Hu, Yi Lv, Zhi-Long Lin, Li Ma, Research Laboratory of Shock and Multiple Organ Dysfunction, Burns Institute, First Hospital Affiliated to the PLA General Hospital, Beijing 100048, China
Ming-Hua Du, Hong-Min Luo, Medical School of Chinese PLA, Beijing 100853, China
Author contributions: Du MH and Luo HM contributed equally to this study; Hu S, Du MH and Luo HM designed the research; Du MH, Luo HM, Lin ZL, Ma L and Lv Y performed the research; Du MH, Hu S and Luo HM analyzed the data; Du MH, Luo HM and Hu S prepared and revised the manuscript. All authors have read and approved the final manuscript.
Supported by The National Basic Research Program of China, 973 Program, Grant No. 2012CB518101
Correspondence to: Sen Hu, MD, PhD, Professor, Chief, Research Laboratory of Shock and Multiple Organ Dysfunction, Burns Institute, First Hospital Affiliated to the PLA General Hospital, No. 51 Fu Cheng Road, Beijing 100048, China. bs0425@163.com
Telephone: +86-10-66867397 Fax: +86-10-68989139
Received: April 28, 2013
Revised: August 11, 2013
Accepted: August 16, 2013
Published online: September 28, 2013
Revised: August 11, 2013
Accepted: August 16, 2013
Published online: September 28, 2013
Core Tip
Core tip: The most important novel findings from this study are that when delayed resuscitation is inevitable during emergency situations such as hemorrhagic shock occurring in war without sufficient fluids, electroacupuncture at ST36 can be performed and it can successfully attenuate systemic inflammation, decrease gut injury and permeability and improve blood pressure and outcomes, which is consistent with preserved intestinal barrier function after hemorrhage and delayed fluid resuscitation.