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World J Gastroenterol. Sep 28, 2013; 19(36): 5981-5987
Published online Sep 28, 2013. doi: 10.3748/wjg.v19.i36.5981
Published online Sep 28, 2013. doi: 10.3748/wjg.v19.i36.5981
Tolerance and chimerism and allogeneic bone marrow/stem cell transplantation in liver transplantation
Sheng-Li Wu, Cheng-En Pan, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Author contributions: Wu SL and Pan CE participated in manuscript writing; Pan CE participated in manuscript review.
Correspondence to: Sheng-Li Wu, MD, PhD, Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, No. 277, Yanta West Road, Xi’an 710061, Shaanxi Province, China. shengliyili@hotmail.com
Telephone: +86-29-85323895 Fax: +86-29-85263190
Received: April 5, 2013
Revised: June 5, 2013
Accepted: July 18, 2013
Published online: September 28, 2013
Revised: June 5, 2013
Accepted: July 18, 2013
Published online: September 28, 2013
Core Tip
Core tip: The liver is considered an immune privileged organ. The main challenge facing liver transplantation is to induce donor-specific tolerance. Numerous reports have documented the phenomenon of microchimerism in liver transplant recipients. Most have demonstrated that higher levels of chimerism in liver transplantation are associated with reduced incidence of acute rejection and better initial graft acceptance. Mechanisms involved in chimerism-induced tolerance have only been partly elucidated. Chimerism can be induced through transplantation of allogeneic donor bone marrow cells under appropriate host conditioning and represents a clinically feasible approach for the induction of durable liver transplantation tolerance.