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World J Gastroenterol. Aug 14, 2013; 19(30): 4950-4957
Published online Aug 14, 2013. doi: 10.3748/wjg.v19.i30.4950
Published online Aug 14, 2013. doi: 10.3748/wjg.v19.i30.4950
Validation of the chronic liver disease questionnaire in Serbian patients
Dusan Dj Popovic, Nada V Kovacevic, Tamara M Alempijevic, Milan M Spuran, Miodrag N Krstic, Rada S Jesic, Clinic for Gastroenterology, Clinical Centre of Serbia, Belgrade 11000, Serbia
Nada V Kovacevic, Tamara M Alempijevic, Darija B Kisic Tepavcevic, Goran Z Trajkovic, Miodrag N Krstic, Rada S Jesic, Tatjana D Pekmezovic, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia
Darija B Kisic Tepavcevic, Tatjana D Pekmezovic, Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia
Goran Z Trajkovic, Institute of Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia
Zobair M Younossi, Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church, Annandale, VA 22003-6800, United States
Author contributions: Popovic DD gave an substantial contributions to conception of the study, as well as in acquisition of data and drafting the article; Kovacevic NV and Younossi ZM gave substantial contributions to conception and design of the research; Kisic Tepavcevic DB had significant contributions in interpretation of data and revising the article critically for important intellectual content; Trajkovic GZ gave essential contributions in analysis and interpretation of data; Alempijevic TM, Spuran MM, Krstic MN and Jesic RS had important contributions in acquisition of data; Pekmezovic TD revised the article critically for important intellectual content and gave a final approval of the version to be published.
Supported by Grant from the Ministry of Education and Science of the Republic of Serbia, No. 175087 to Pekmezovic TD, Kisic Tepavcevic DB and Trajkovic GZ
Correspondence to: Tatjana D Pekmezovic, MD, Chief, Professor of Medicine, Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Visegradska 26A, Belgrade 11000, Serbia. pekmezovic@sezampro.rs
Telephone: +381-11-3607062 Fax: +381-11-3607062
Received: April 15, 2013
Revised: June 5, 2013
Accepted: June 19, 2013
Published online: August 14, 2013
Processing time: 119 Days and 16.1 Hours
Revised: June 5, 2013
Accepted: June 19, 2013
Published online: August 14, 2013
Processing time: 119 Days and 16.1 Hours
Core Tip
Core tip: The Serbian validation of the chronic liver disease questionnaire (CLDQ) confirmed the 6-domain structure of the original United States version. However, in our investigation the original structure was only partially reproduced. The most prominent changes are related to the fact that the factors “Activity” and “Abdominal symptoms” could not be replicated, and two new domains “Sleep” and “Nutrition” were established Moreover, the domain “Nutrition” has been introduced for the first time. Our results of factors analysis gave the evidence that at list some items from the original version of CLDQ should be allocated or eliminated from the questionnaire because of the multiple loadings.