Copyright
©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jul 28, 2013; 19(28): 4582-4589
Published online Jul 28, 2013. doi: 10.3748/wjg.v19.i28.4582
Published online Jul 28, 2013. doi: 10.3748/wjg.v19.i28.4582
Antinociceptive effect of berberine on visceral hypersensitivity in rats
Qing-Lin Tang, Min-Ling Lai, Yuan-Fu Zhong, Ai-Min Wang, Jun-Kai Su, Ming-Qing Zhang, Department of Gastroenterology, 175th Hospital of PLA, Affiliated Southeast Hospital of Xiamen University, Zhangzhou 363000, Fujian Province, China
Author contributions: Zhang MQ and Tang QL designed the research; Tang QL, Lai ML, Zhong YF and Wang AM performed the experiments; Tang QL and Su JK analyzed the data; Tang QL, Zhong YF, Su JK and Wang AM wrote and revised the manuscript; Zhang MQ supervised the whole research and revised the manuscript.
Correspondence to: Ming-Qing Zhang, Professor, Department of Gastroenterology, 175th Hospital of PLA, Affiliated Southeast Hospital of Xiamen University, No. 269 Middle Zhanghua Road, Zhangzhou 363000, Fujian Province, China. zhangmingqing20@163.com
Telephone: +86-596-2975571 Fax: +86-596-2975771
Received: May 13, 2013
Revised: May 28, 2013
Accepted: June 8, 2013
Published online: July 28, 2013
Processing time: 116 Days and 12.2 Hours
Revised: May 28, 2013
Accepted: June 8, 2013
Published online: July 28, 2013
Processing time: 116 Days and 12.2 Hours
Core Tip
Core tip: Berberine had an antinociceptive effect on visceral hypersensitivity. This effect was reduced by nitric oxide (NO) synthetase inhibitor, thus NO might play a role in the effect of berberine.