Li GG, Li L, Li C, Ye LY, Li XW, Liu DR, Bao Q, Zheng YX, Xiang DP, Chen L, Chen J. Influence of up-regulation of Notch ligand DLL4 on biological behaviors of human gastric cancer cells. World J Gastroenterol 2013; 19(28): 4486-4494 [PMID: 23901223 DOI: 10.3748/wjg.v19.i28.4486]
Corresponding Author of This Article
Dr. Jian Chen, PhD, Department of Surgery, Second Affiliated Hospital, College of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. chenjian_zju@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Original Article
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World J Gastroenterol. Jul 28, 2013; 19(28): 4486-4494 Published online Jul 28, 2013. doi: 10.3748/wjg.v19.i28.4486
Influence of up-regulation of Notch ligand DLL4 on biological behaviors of human gastric cancer cells
Guo-Gang Li, Lan Li, Chao Li, Long-Yun Ye, Xiao-Wen Li, Da-Ren Liu, Qi Bao, Yi-Xiong Zheng, Da-Peng Xiang, Li Chen, Jian Chen
Guo-Gang Li, Chao Li, Long-Yun Ye, Xiao-Wen Li, Da-Ren Liu, Qi Bao, Yi-Xiong Zheng, Da-Peng Xiang, Li Chen, Jian Chen, Department of Surgery, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China
Lan Li, Department of Gastroenterology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Author contributions: Chen J designed the study; Li GG, Li C, Ye LY, Li XW, Liu DR, Bao Q, Zheng YX and Xiang DP carried out the study; Li GG, Chen L and Chen J analyzed the data; Li GG and Li L wrote the paper; all the authors contributed to the preparation of the manuscript.
Supported by The Key Project of Science and Technology of Zhejiang Province, No. 2009C14017; the National Natural Science Foundation of China, No. 81071959 and No. 81101837; the Zhejiang Provincial Medical and Healthy Science Foundation of China, No. 2013KYA100 and No. 2009B043; and the Public Welfare Technology Research Project of Zhejiang Province, No. 2010C34001
Correspondence to: Dr. Jian Chen, PhD, Department of Surgery, Second Affiliated Hospital, College of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. chenjian_zju@163.com
Telephone: +86-571-87783582 Fax: +86-571-87022776
Received: April 18, 2013 Revised: June 11, 2013 Accepted: June 19, 2013 Published online: July 28, 2013 Processing time: 101 Days and 23.9 Hours
Core Tip
Core tip: Delta-like ligand 4 (DLL4), one of the five notch signaling ligands in mammals, has been researched mainly with regard to vasculogenesis and tumor angiogenesis. To the best of our knowledge, there is rare study to investigate its role and mechanism in human gastric cancers. We found that DLL4 promotes cellular proliferation, migration, invasion and tumorigenicity in gastric cancer cells. Furthermore, increased mRNA level and increased secretion of matrix metalloproteinase-2 proenzyme, while increased matrix metalloproteinase (MMP)-9 mRNA levels but decreased extracellular MMP-9 proenzyme levels were observed. These results indicated a mechanism by which activation of DLL4-mediated Notch signaling promotes the expression and secretion of MMP-2 proenzyme and influences the progress of gastric cancer.
