Review
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World J Gastroenterol. Jul 28, 2013; 19(28): 4455-4463
Published online Jul 28, 2013. doi: 10.3748/wjg.v19.i28.4455
Autoimmune hepatitis in childhood: The role of genetic and immune factors
Priscila Menezes Ferri Liu, Débora Marques de Miranda, Eleonora Druve Tavares Fagundes, Alexandre Rodrigues Ferreira, Ana Cristina Simões e Silva
Priscila Menezes Ferri Liu, Débora Marques de Miranda, Eleonora Druve Tavares Fagundes, Alexandre Rodrigues Ferreira, Ana Cristina Simões e Silva, Department of Pediatrics, Interdisciplinary Laboratory of Medical Investigation, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 30130-100, Brazil
Débora Marques de Miranda, Ana Cristina Simões e Silva, National Institute of Science and Technology of Molecular Medicine, (INCT-MM) CNPq-FAPEMIG, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 30130-100, Brazil
Author contributions: Miranda DM, Fagundes EDT and Ferreira AR designed the research; Ferri Liu PM performed the research; Ferri Liu PM, Miranda DM, Ferreira AR and Simoes e Silva AC wrote the paper; all authors reviewed final version.
Supported by CAPES, INCT-MM (FAPEMIG: CBB-APQ-00075-09/CNPq 573646/2008-2)
Correspondence to: Ana Cristina Simões e Silva, MD, PhD, Department of Pediatrics, Interdisciplinary Laboratory of Medical Investigations, Federal University of Minas Gerais, Avenida Alfredo Balena 190, 2nd floor, Room 281, Belo Horizonte, Minas Gerais 30130-100, Brazil. acssilva@hotmail.com
Telephone: +55-31-34098073 Fax: +55-31-34099772
Received: April 7, 2013
Revised: June 5, 2013
Accepted: June 8, 2013
Published online: July 28, 2013
Processing time: 113 Days and 1.3 Hours
Core Tip

Core tip: In this review article, we reported recent data on autoimmune hepatitis in pediatric patients highlighting the importance of genetic and immune markers. We also discuss the perspectives of the application of these new biomarkers in clinical practice.