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World J Gastroenterol. Jul 28, 2013; 19(28): 4447-4454
Published online Jul 28, 2013. doi: 10.3748/wjg.v19.i28.4447
Published online Jul 28, 2013. doi: 10.3748/wjg.v19.i28.4447
Interplay of autophagy and innate immunity in Crohn's disease: A key immunobiologic feature
Györgyi Műzes, Zsolt Tulassay, Ferenc Sipos, 2nd Department of Internal Medicine, Semmelweis University, 1088 Budapest, Hungary
Author contributions: Műzes G wrote the manuscript; Tulassay Z and Sipos F contributed in editing and revising the manuscript.
Correspondence to: Györgyi Műzes, MD, PhD, Associate Professor of Immunology and Internal Medicine, 2nd Department of Internal Medicine, Semmelweis University, Szentkirályi str. 46, 1088 Budapest, Hungary. muzes.gyorgyi@med.semmelweis-univ.hu
Telephone: +36-12-660926 Fax: +36-12-660816
Received: May 29, 2013
Revised: June 19, 2013
Accepted: July 4, 2013
Published online: July 28, 2013
Processing time: 61 Days and 9.9 Hours
Revised: June 19, 2013
Accepted: July 4, 2013
Published online: July 28, 2013
Processing time: 61 Days and 9.9 Hours
Core Tip
Core tip: In case of Crohn's disease, on the basis of autophagy-related risk genetic polymorphisms impaired sensing and responding of intracellular bacteria by innate immunity, closely interrelated with the autophagic and unfolded protein pathways seem to be the most relevant immunobiologic events. Autophagy represents a key regulator mechanism with the capacity to integrate several aspects of Crohn's disease pathogenesis.