Factors influencing clinical outcomes of Histoacryl&reg; glue injection-treated gastric variceal hemorrhage

doi:10.3748/wjg.v19.i15.2379

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 21, 2013; 19(15): 2379-2387
Published online Apr 21, 2013. doi: 10.3748/wjg.v19.i15.2379

Factors influencing clinical outcomes of Histoacryl^® glue injection-treated gastric variceal hemorrhage

Varayu Prachayakul, Pitulak Aswakul, Tanyaporn Chantarojanasiri, Somchai Leelakusolvong

Varayu Prachayakul, Pitulak Aswakul, Tanyaporn Chantarojanasiri, Somchai Leelakusolvong, Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Mahidol University, Siriraj Hospital, Bangkok 10700, Thailand

Pitulak Aswakul, Liver and Digestive Institute, Samitivej Sukhumvit Hospital, Bangkok 10700, Thailand

Author contributions: Chantarojanasiri T acquired the data; Leelakusolvong S critically assessed the manuscript’s intellectual content; Aswakul P conceptualized and designed the study, analyzed and interpreted the data, drafted and revised the manuscript; Prachayakul V conceptualized and designed the study, analyzed and interpreted the data, and critically assessed and revised the manuscript’s intellectual content.

Correspondence to: Dr. Varayu Prachayakul, Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Mahidol University, Siriraj Hospital, 2 Prannok road, Siriraj, Bangkok Noi, Bangkok 10700, Thailand. kaiyjr@gmail.com

Telephone: +66-2-4121088 Fax: +66-2-4199610

Received: November 19, 2012
Revised: January 3, 2013
Accepted: January 23, 2013
Published online: April 21, 2013
Processing time: 151 Days and 10.5 Hours

Core Tip

Core tip: Acute gastric variceal hemorrage is associated with a high mortality rate which accounts for one third of the patients. Histoacryl^® injection has been reported as one of the effective procedures for treating this condition. The present study investigated patients presenting with acute gastric variceal hemorrage and found that Histoacryl^® injection was a safe and highly effective hemostatic method for treating gastric variceal hemorrhage with 97.8% initial hemostasis; only a 10% early re-bleeding rate and a 14.4% procedure-related complication rate were found. The risk factors for re-bleeding were compromised liver status and presence of ascites.