Brief Article
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World J Gastroenterol. Apr 7, 2013; 19(13): 2073-2079
Published online Apr 7, 2013. doi: 10.3748/wjg.v19.i13.2073
Clinicopathological and prognostic significance of galectin-1 and vascular endothelial growth factor expression in gastric cancer
Jie Chen, Su-Jun Zhou, Yun Zhang, Guo-Qiang Zhang, Tian-Zhou Zha, Yi-Zhong Feng, Kai Zhang
Jie Chen, Su-Jun Zhou, Yun Zhang, Guo-Qiang Zhang, Tian-Zhou Zha, Kai Zhang, Department of General Surgery, Yixing People’s Hospital, the Affiliated Hospital of Jiangsu University, Yixing 214200, Jiangsu Province, China
Yi-Zhong Feng, Department of Pathology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China
Author contributions: Chen J carried out data analysis and wrote the manuscript; Zhou SJ designed this study and performed the statistical analyses; Zhang Y, Zhang GQ, Feng YZ and Zha TZ participated in clinicopathological data collection; Chen J and Zhang K scored the immunostained slides, prepared the images and reviewd the manuscript.
Correspondence to: Kai Zhang, MD, Department of General Surgery, Yixing People’s Hospital, the Affiliated Hospital of Jiangsu University, No. 75, Tongzhen Guan Road, Yixing 214200, Jiangsu Province, China. yxphpwk@163.com
Telephone: +86-510-87071163 Fax: +86-510-87918767
Received: December 18, 2012
Revised: January 28, 2013
Accepted: February 5, 2013
Published online: April 7, 2013
Processing time: 111 Days and 18.9 Hours
Core Tip

Core tip: Galectin-1 and vascular endothelial growth factor (VEGF) played important roles in angiogenesis and progression of malignant tumor, while their expression in Chinese gastric cancer and relationship between the two parameters and clinicopathological features, as well as prognostic value remained largely unknown. In this present study, we examined 214 gastric cancer samples for the presence of galectin-1 oncoprotein and VEGF by immunohistochemistry and found that overexpressions of galectin-1 and VEGF were related with tumor progression and poor survival, and our findings supported an association between galectin-1 and VEGF expression. These two molecules may serve as independent predicative markers for patient prognosis in gastric cancer.