Meng YT, Zhou Y, Han PY, Ren HB. Ferroptosis inhibition attenuates inflammatory response in mice with acute hypertriglyceridemic pancreatitis. World J Gastroenterol 2023; 29(15): 2294-2309 [PMID: 37124891 DOI: 10.3748/wjg.v29.i15.2294]
Corresponding Author of This Article
Hong-Bo Ren, PhD, Professor, Department of Gastroenterology, Qilu Hospital, No. 107 Wenhuaxi Road, Jinan 250012, Shandong Province, China. rhb2229@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Apr 21, 2023; 29(15): 2294-2309 Published online Apr 21, 2023. doi: 10.3748/wjg.v29.i15.2294
Ferroptosis inhibition attenuates inflammatory response in mice with acute hypertriglyceridemic pancreatitis
Yi-Teng Meng, Yi Zhou, Pei-Yu Han, Hong-Bo Ren
Yi-Teng Meng, Department of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong Province, China
Yi Zhou, Pei-Yu Han, Wuxi School of Medicine, Jiangnan University, Wuxi 214000, Jiangsu Province, China
Hong-Bo Ren, Department of Gastroenterology, Qilu Hospital, Jinan 250012, Shandong Province, China
Author contributions: Meng YT, Zhou Y, Han PY, and Ren HB designed the study; Meng YT, Zhou Y and Han PY participated in data collection and wrote the paper; Ren HB and Han PY were responsible for revising the manuscript, contributing the same to the paper; All the listed authors have contributed and approved the final manuscript.
Supported bythe National Natural Science Foundation of Shandong Province, No. ZR2021MH032.
Institutional animal care and use committee statement: This study was approved by the Ethics Committee of Scientific Research of Jinan University Application for Laboratory Animal Ethical Review, No. 20210303-06.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Bo Ren, PhD, Professor, Department of Gastroenterology, Qilu Hospital, No. 107 Wenhuaxi Road, Jinan 250012, Shandong Province, China. rhb2229@163.com
Received: December 6, 2022 Peer-review started: December 6, 2022 First decision: January 22, 2023 Revised: February 20, 2023 Accepted: March 21, 2023 Article in press: March 21, 2023 Published online: April 21, 2023 Processing time: 129 Days and 12.7 Hours
ARTICLE HIGHLIGHTS
Research background
Ferroptosis is involved in the development of inflammatory diseases, but its relationship with acute hypertriglyceridemic pancreatitis (HTGP) remains unclear.
Research motivation
HTGP has serious morbidity and high mortality. At present, there is no more effective method except symptomatic treatment. Therefore, exploring the pathogenesis of HTGP and seeking more accurate therapeutic targets are of critical importance.
Research objectives
This study aimed to explore whether ferroptosis is involved in the process of HTGP and elucidate its potential mechanisms in a mouse model.
Research methods
Pancreatic tissues from the model animals were subjected to proteome sequencing analysis. The pathological changes and scores of the pancreas, lung, and kidney were determined using hematoxylin–eosin staining. The levels of serum amylase, triglyceride, and total cholesterol were measured with an automatic blood cell analyzer. Additionally, the serum levels of tumor necrosis factor-α, interleukin (IL)-6, and IL-1β were determined by enzyme linked immunosorbent assay. Malonaldehyde, glutathione, and Fe2+ were detected in the pancreas. Finally, immunohistochemistry was performed to assess the expression of ferroptosis-related proteins.
Research results
Proteome sequencing revealed that ferroptosis was involved in the process of HTGP and that NADPH oxidase 2 may participate in ferroptosis regulation.
Research conclusions
Ferroptosis was found to have an important role in HTGP and may be considered a potential target for clinical treatment.
Research perspectives
This discovery provides new insights into a better understanding of the pathogenesis of HTGP, which may be used as a novel therapeutic target. However, the regulatory mechanism needs to be further explored in the future.
