Brief Reports
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 15, 2003; 9(8): 1853-1855
Published online Aug 15, 2003. doi: 10.3748/wjg.v9.i8.1853
Expression of class I MHC molecule, HSP70 and TAP in human hepatocellular carcinoma
Xiao-Ling Deng, Wei Chen, Mei-Ying Cai, Da-Peng Wei
Xiao-Ling Deng, Wei Chen, Mei-Ying Cai, Da-Peng Wei, Immunology Department, West China Medical Center of Sichuan University, Chengdu 610044, Sichuan Province, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No. 30070855
Correspondence to: Da-Peng Wei, Immunology Department, West China Medical Center of Sichuan University, Chengdu 610044, Sichuan Province, China. dengxiaoling@163.com
Telephone: +86-28-85501259
Received: December 22, 2002
Revised: January 6, 2003
Accepted: January 18, 2003
Published online: August 15, 2003
Abstract

AIM: To demonstrate whether class I MHC molecule, transporter associated with antigen processing (TAP), and heat-shock proteion70 (HSP70) expressed in liver cancer cells before the design and construction of CTL vaccine against hepatocellular carcinoma (HCC).

METHODS: We studied 30 HCC specimens by labeled streptavidin biotin (LSAB) method of immunohistochemistry.

RESULTS: The results showed that the majority of HCC cells investigated naturally expressed class I MHC and TAP, which were different from other tumor cells. Furthermore, we found that HSP70 expressed not only in cellular cytoplasm, but also on the cell surface in HCC.

CONCLUSION: Our findings indicate that our understanding about immune escape mechanisms employed by HCC cells may be further improved. It is important to design and construct CTL vaccine against HCC.

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