Effect of Sea buckthorn on liver fibrosis: A clinical study

doi:10.3748/wjg.v9.i7.1615

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 15, 2003; 9(7): 1615-1617
Published online Jul 15, 2003. doi: 10.3748/wjg.v9.i7.1615

Effect of Sea buckthorn on liver fibrosis: A clinical study

Ze-Li Gao, Xiao-Hong Gu, Feng-Tao Cheng, Fo-Hu Jiang

Ze-Li Gao, Fo-Hu Jiang, Department of Gastroenterology, Baogang Hospital, Shanghai Second Medical University, Shanghai 201900, China

Xiao-Hong Gu, Feng-Tao Cheng, Department of Gastroenterology, Yangpu District Hospital, Shanghai 200090, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Ze-Li Gao, Department of Gastroenterology, Baogang Hospital, Shanghai Second Medical University, Shanghai 201900, China. gzeli@sina.com

Telephone: +86-21-56691101-6260

Received: December 28, 2002
Revised: January 14, 2003
Accepted: February 18, 2003
Published online: July 15, 2003

Abstract

AIM: To appraise the effect of sea buckthorn (Hippophae rhamnoides) on cirrhotic patients.

METHODS: Fifty cirrhotic patients of Child-Pugh grade A and B were randomly divided into two groups: Group A as the treated group (n = 30), taking orally the sea buckthorn extract, 15 g 3 times a day for 6 mo. Group B as the control group (n = 18), taking vitamin B complex one tablet, 3 times a day for 6 mo. The following tests were performed before and after the treatment in both groups to determine LN, HA, collagens types III and IV, cytokines IL-6 and TNFα, liver serum albumin, total bile acid, ALT, AST and prothrombin time.

RESULTS: The serum levels of TNFα, IL-6, laminin and type IV collagen in group A were significantly higher than those in the control group. After a course of sea buckthorn treatment, the serum levels of LN, HA, collagen types III and IV, total bile acid (TBA) decreased significantly as compared with those before and after treatment in the control group. The sea buckthorn notably shortened the duration for normalization of aminotransferases.

CONCLUSION: Sea buckthorn may be a hopeful drug for prevention and treatment of liver fibrosis.

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