Basic Research
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 15, 2003; 9(7): 1563-1566
Published online Jul 15, 2003. doi: 10.3748/wjg.v9.i7.1563
Effect of tetramethylpyrazine on P-selectin and hepatic/renal ischemia and reperfusion injury in rats
Jin-Lian Chen, Tong Zhou, Wei-Xiong Chen, Jin-Shui Zhu, Ni-Wei Chen, Ming-Jun Zhang, Yun-Lin Wu
Jin-Lian Chen, Wei-Xiong Chen, Jin-Shui Zhu, Ni-Wei Chen, Department of Gastroenterology, Shanghai Sixth People's Hospital, Shanghai Jiao-Tong University, Shanghai 200233, China
Tong Zhou, Department of Nephrology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
Ming-Jun Zhang, Animal Laboratory, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
Yun-Lin Wu, Department of Gastroenterology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China (No.39970340) and the Scientific Foundation of Ministry of Public Health
Correspondence to: Jin-Lian Chen, Department of Gastroenterology, Shanghai Sixth People's Hospital, Shanghai Jiao-Tong University, Shanghai 200233, China. cqinqin@fm365.com
Telephone: +86-21-64369181
Received: December 30, 2002
Revised: February 4, 2003
Accepted: February 19, 2003
Published online: July 15, 2003
Abstract

AIM: To investigate the effect of tetramethylpyrazine on hepatic/renal ischemia and reperfusion injury in rats.

METHODS: Hepatic/renal function, histopathological changes, and hepatic/renal P-selectin expression were studied with biochemical measurement and immunohistochemistry in hepatic/renal ischemia and reperfusion injury in rat models.

RESULTS: Hepatic/renal insufficiency and histopathological damage were much less in the tetramethylpyrazine-treated group than those in the saline-treated groups. Hepatic/renal P-selectin expression was down regulated in the tetramethylpyrazine-treated group.

CONCLUSION: P-selectin might mediate neutrophil infiltration and contribute to hepatic/renal ischemia and reperfusion injury. Tetramethylpyrazine might prevent hepatic/renal damage induced by ischemia and reperfusion injury through inhibition of P-selectin.

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