Basic Research
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 15, 2003; 9(7): 1545-1549
Published online Jul 15, 2003. doi: 10.3748/wjg.v9.i7.1545
Improvements of postburn renal function by early enteral feeding and their possible mechanisms in rats
Li Zhu, Zong-Cheng Yang, De-Chang Chen
Li Zhu, Department of Anesthesiology, Naval General Hospital, Beijing 100037, China
Zong-Cheng Yang, Institute of Burn Research, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
De-Chang Chen, Department of Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
Author contributions: All authors contributed equally to the work.
Supported by National Natural Science Foundation of China, No. 30290700
Correspondence to: Dr. Zhu Li, Department of Anesthesiology, Naval General Hospital, Beijing 100037, China. zlicu@mail.china.com
Telephone: +86-10-68589503
Received: April 2, 2003
Revised: May 4, 2003
Accepted: May 19, 2003
Published online: July 15, 2003
Abstract

AIM: To investigate the protective effects of early enteral feeding (EEF) on postburn impairments of renal function and their possible mechanisms.

METHODS: Wistar rats with 30% of total body surface area (TBSA) full-thickness burn were adopted as the experimental model. The effects of EEF on the postburn changes of gastric intramucosal pH(pHi), endotoxin levels in portal vein, water contents of renal tissue, and blood concentrations of tumor necrosis factor (TNF-α), urea nitrogen (BUN), creatinine (Cr), as well as the changes of clearance of creatinine (CCr) were dynamically observed within 48 h postburn.

RESULTS: EEF could significantly improve gastric mucosal acidosis, reduce portal vein endotoxin levels and water contents of renal tissue, as well as blood concentrations of TNF-α after severe burns (P < 0.01). The postburn elevations of BUN and BCr were not found to be recovered by EEF. However, the CCr in EEF group was greatly increased by 4.67-fold compared with that of the non-feeding burned control (16.43 ± 2.90 vs. 3.52 ± 0.79, P < 0.01).

CONCLUSION: EEF has beneficial effects on the improvement of renal function in severely burned rats, which may be related to its increase of splanchnic blood flow, decrease of the translocation of gut-origin endotoxin and the release of inflammatory mediators.

Keywords: $[Keywords]