Esophageal Cancer
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 15, 2003; 9(7): 1390-1393
Published online Jul 15, 2003. doi: 10.3748/wjg.v9.i7.1390
NQO1 C609T polymorphism associated with esophageal cancer and gastric cardiac carcinoma in North China
Jian-Hui Zhang, Yan Li, Rui Wang, Helen Geddert, Wei Guo, Deng-Gui Wen, Zhi-Feng Chen, Li-Zhen Wei, Gang Kuang, Ming He, Li-Wei Zhang, Ming-Li Wu, Shi-Jie Wang
Jian-Hui Zhang, Yan Li, Rui Wang, Wei Guo, Deng-Gui Wen, Zhi-Feng Chen, Li-Zhen Wei, Gang Kuang, Ming He, Li-Wei Zhang, Ming-Li Wu, Shi-Jie Wang, Hebei Cancer Institute and the Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Helen Geddert, Institute of Pathology, University of Duesseldorf, Moorenstr.5 40225 Duesseldorf, Germany
Author contributions: All authors contributed equally to the work.
Supported by the "Stiftung fÜr Altersforschung" of Germany (grant number: 701800167) and Scientific Grant of Educational Department of Hebei Province, China (grant number: 2001150)
Correspondence to: Professor Shi-Jie Wang, The Fourth Affiliated Hospital of Hebei Medical University, Jiankanglu 12, Shijiazhuang 050011, China. wang.sj@hbmu.edu
Telephone: +86-311-6085231 Fax: +86-311-6077634
Received: December 24, 2002
Revised: January 4, 2003
Accepted: February 11, 2003
Published online: July 15, 2003
Abstract

AIM: To investigate the association of the NQO1 (C609T) polymorphism with susceptibility to esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in North China.

METHODS: The NQO1 C609T genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in 317 cancer patients (193 ESCC and 124 GCA) and 165 unrelated healthy controls.

RESULTS: The NQO1 C609T C/C, C/T and T/T genotype frequency among healthy controls was 31.5%, 52.1% and 16.4% respectively. The NQO1 T/T genotype frequency among ESCC patients (25.9%) was significantly higher than that among healthy controls (χ2 = 4.79, P = 0.028). The NQO1 T/T genotype significantly increased the risk for developing ESCC compared with the combination of C/C and C/T genotypes, with an age, sex and smoking status adjusted odds ratio (OR) of 1.78 (1.04-2.98). This increased susceptibility was pronounced in ESCC patients with family histories of upper gastrointestinal cancers (UGIC) (adjusted OR = 2.20, 95%CI: 1.18-3.98). Similarly, the susceptibility of the NQO1 T/T genotype to GCA development was also observed among patients with family histories of UGIC, with an adjusted odds ratio of 2.55 (95%CI: 1.21-5.23), whereas no difference in NQO1 genotype distribution was shown among patients without family histories of UGIC.

CONCLUSION: Determination of the NQO1 C609T genotype may be used as a stratification marker to predicate the individuals at high risk for developing ESCC and GCA in North China.

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