Brief Reports
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 15, 2003; 9(5): 1123-1125
Published online May 15, 2003. doi: 10.3748/wjg.v9.i5.1123
Effects of antireflux treatment on bronchial hyper-responsiveness and lung function in asthmatic patients with gastroesophageal reflux disease
Shan-Ping Jiang, Rui-Yun Liang, Zhi-Yong Zeng, Qi-Liang Liu, Yong-Kang Liang, Jian-Guo Li
Shan-Ping Jiang, Rui-Yun Liang, Qi-Liang Liu, Yong-Kang Liang, Jian-Guo Li, Department of Respiratory Medicine, The Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510120, Guangdong Province, China
Zhi-Yong Zeng, Department of Gastroenterology, The Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510120, Guangdong Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Professor Shan-Ping Jiang, Department of respiratory Medicine, The Second Affiliated Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou 510120, Guangdong Province China. zengzhiyong99@hotmail.com
Telephone: +86-20-81332441 Fax: +86-20-81332441
Received: December 22, 2002
Revised: January 5, 2003
Accepted: January 16, 2003
Published online: May 15, 2003
Abstract

AIM: To investigate the effects of antireflux treatment on bronchial hyper-responsiveness and lung function in asthmatic patients with gastroesophageal reflux disease (GERD).

METHODS: Thirty asthmatic patients with GERD were randomly divided into two groups (group A and group B). Patients in group A (n = 15) only received asthma medication including inhaled salbutamol 200 μg four times a day and budesonide 400 μg twice a day for 6 weeks. Patients in Group B (n = 15) received the same medication as group A, and also antireflux therapy including oral omeprazole 20 mg once a day and domperidone 10 mg three times a day for 6 weeks. Pulmonary function tests and histamine bronchoprovocation test were performed before and after the study.

RESULTS: There was no significant difference in the baseline values of pulmonary function and histamine PC20-FEV1 between the two groups. At the end of the study, the mean values for VC, VC%, FVC, FVC%, FEV1, FEV1%, PEF, PEF%, PC20-FEV1 were all significantly improved in group B, compared with

group A.

CONCLUSION: Antireflux therapy may improve pulmonary function and inhibit bronchial hyper-responsiveness in asthmatic patients with GERD.

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