Basic Research
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 15, 2003; 9(5): 1054-1057
Published online May 15, 2003. doi: 10.3748/wjg.v9.i5.1054
Expression of a novel immunoglobulin gene SNC73 in human cancer and non-cancerous tissues
Jian-Bin Hu, Shu Zheng, Yong-Chuan Deng
Jian-Bin Hu, Department of Radiation Oncology, Sir Run Run Shaw Hospital, Zhejiang University Medical College, Hangzhou 310016, Zhejiang Province, China
Shu Zheng, Cancer Institute, Zhejiang University, Hangzhou 310009, Zhejiang Province, China
Yong-Chuan Deng, Department of Surgical Oncology, The Second Affiliated Hospital of Zhejiang University Medical College, Hangzhou 310009, Zhejiang Province, China
Author contributions: All authors contributed equally to the work.
Supported by the National Nature Scientific Foundation of China, No. 30070832
Correspondence to: Shu Zheng, Cancer Institute, Zhejiang University, Hangzhou 310009, Zhejiang Province, China. zhengshu@mail.hz.zj.cn
Telephone: +86-571-87783868 Fax: +86-571-87214404
Received: June 11, 2002
Revised: June 23, 2002
Accepted: July 12, 2002
Published online: May 15, 2003
Abstract

AIM: To investigate the expression of immunoglobulin gene SNC73 in malignant tumors and non-cancerous normal tissues.

METHODS: Expression level of SNC73 in tumors and non-cancerous tissues from the same patient was determined by reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay (RT-PCR-ELISA) in 90 cases of malignant tumors, including colorectal cancer, gastric cancer, breast cancer, lung cancer and liver cancer. Analysis on the correlation of SNC73 expression with sex, age, site, grade of differentiation, depth of invasion, and metastases in colorectal cancer patients was made.

RESULTS: Expression level of SNC73 in non-cancerous colorectal mucosa and colorectal cancerous tissues was 1.234 ± 0.842 and 0.737 ± 0.731, respectively (P < 0.01), with the mean ratio of 7.134 ± 14.092 (range, 0.36-59.54). Expression of SNC73 showed no significant difference among gastric cancer, breast cancer, lung cancer and liver cancer when compared with non-cancerous tissues (P > 0.05). No correlation was found between SNC73 expression level and various clinicopathological factors, including sex, age, site, grade of differentiation, depth of invasion and metastases of CRC patients.

CONCLUSION: Down-regulation of SNC73 expression may be a relatively specific phenomenon in colorectal cancer. SNC73 is a potential genetic marker for the carcinongenesis of colorectal cancer. The relationship of SNC73 expression and carcinogenesis of colorectal cancer merits further study.

Keywords: $[Keywords]