Brief Reports
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 15, 2003; 9(11): 2605-2608
Published online Nov 15, 2003. doi: 10.3748/wjg.v9.i11.2605
Restenosis following balloon dilation of benign esophageal stenosis
Ying-Sheng Cheng, Ming-Hua Li, Ren-Jie Yang, Hui-Zhen Zhang, Zai-Xian Ding, Qi-Xin Zhuang, Zhi-Ming Jiang, Ke-Zhong Shang
Ying-Sheng Cheng, Ming-Hua Li, Qi-Xin Zhuang, Ke-Zhong Shang, Department of Radiology, Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China
Ren-Jie Yang, Department of Interventional Diagnosis and Therapy, Clinical Oncology College of Beijing University, Beijing 100036, China
Hui-Zhen Zhang, Zhi-Ming Jiang, Department of Pathology, Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China
Zai-Xian Ding, Department of Animal Experiment, Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China
Author contributions: All authors contributed equally to the work.
Supported by the National Key Technologies Research and Development Program of China During the 9th Five-Year Plan Period, No.96-907-03-04
Correspondence to: Dr. Ying-Sheng Cheng, Department of Radiology, Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China. chengys@sh163.net
Telephone: +86-21-64368920 Fax: +86-21-64701361
Received: May 13, 2003
Revised: May 23, 2003
Accepted: June 2, 2003
Published online: November 15, 2003
Abstract

AIM: To elucidate the mechanism of restenosis following balloon dilation of benign esophageal stenosis.

METHODS: A total of 49 rats with esophageal stenosis were induced in 70 rats using 5 mL of 50% sodium hydroxide solution and the double-balloon method, and an esophageal restenosis (RS) model was developed by esophageal stenosis using dilation of a percutaneous transluminal coronary angioplasty (PTCA) balloon catheter. These 49 rats were divided into two groups: rats with benign esophageal stricture caused by chemical burn only (control group, n = 21) and rats with their esophageal stricture treated with balloon catheter dilation (experimental group, n = 28). Imaging analysis and immunohistochemistry were used for both quantitative and qualitative analyses of esophageal stenosis and RS formation in the rats, respectively.

RESULTS: Cross-sectional areas and perimeters of the esophageal mucosa layer, muscle layer, and the entire esophageal layers increased significantly in the experimental group compared with the control group. Proliferating cell nuclear antigen (PCNA) was expressed on the 5th day after dilation, and was still present at 1 mo. Fibronectin (FN) was expressed on the 1st day after dilation, and was still present at 1 month.

CONCLUSION: Expression of PCNA and FN plays an important role in RS after balloon dilation of benign esophageal stenosis.

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