Model of gastric precancerous lesions for rats

doi:10.3748/wjg.v6.iSuppl3.39

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 39-39
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.39

Model of gastric precancerous lesions for rats

Mao-Xiang Yan, Zhi-Yun Chen, Bai-Kang Xiang

Mao-Xiang Yan, Zhi-Yun Chen, Bai-Kang Xiang, The Digestive Diseases Research Unit of Zhejiang T.C.M. Hospital, Hangzhou 310006, Zhejiang Province, China

Author contributions: All authors contributed equally to the work.

Supported by the Natural Science Foundation of the Scientific and Technological Commission of Zhejiang Province, No. 943017

Correspondence to: Dr. Mao-Xiang Yan, Zhejiang T.C.M. Hospital, No. 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China

Received: December 22, 1999
Revised: March 24, 2000
Accepted: April 23, 2000
Published online: September 15, 2000

Abstract

AIM: To establish an ideal model of gastric precancerous lesions for rats.

METHODS: Fifty rats were fed with carcinogen MNNG for 35 wk and heat-plaste at 60 °C for 20 wk, the pathological changes were observed. Data in the groups were analyzed by Ridit test.

RESULTS: The occurrence rate of dysplasia in rats due to MNNG and heat damage was 65%, which was obviously higher than that due to MNNG only. The differences between the two groups were significant.

CONCLUSION: The animal model made by MNNG and heat damage was an ideal one which could be used to investigate the pathologic mechanism of gastric precancerous lesions.

Keywords: Gastric mucosa, precancerous conditions; Stomach neoplasms, carcinogens; Carcinogenicity test, rats