Copyright
©The Author(s) 2000. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 39-39
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.39
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.39
Model of gastric precancerous lesions for rats
Mao-Xiang Yan, Zhi-Yun Chen, Bai-Kang Xiang, The Digestive Diseases Research Unit of Zhejiang T.C.M. Hospital, Hangzhou 310006, Zhejiang Province, China
Author contributions: All authors contributed equally to the work.
Supported by the Natural Science Foundation of the Scientific and Technological Commission of Zhejiang Province, No. 943017
Correspondence to: Dr. Mao-Xiang Yan, Zhejiang T.C.M. Hospital, No. 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China
Received: December 22, 1999
Revised: March 24, 2000
Accepted: April 23, 2000
Published online: September 15, 2000
Revised: March 24, 2000
Accepted: April 23, 2000
Published online: September 15, 2000
Abstract
AIM: To establish an ideal model of gastric precancerous lesions for rats.
METHODS: Fifty rats were fed with carcinogen MNNG for 35 wk and heat-plaste at 60 °C for 20 wk, the pathological changes were observed. Data in the groups were analyzed by Ridit test.
RESULTS: The occurrence rate of dysplasia in rats due to MNNG and heat damage was 65%, which was obviously higher than that due to MNNG only. The differences between the two groups were significant.
CONCLUSION: The animal model made by MNNG and heat damage was an ideal one which could be used to investigate the pathologic mechanism of gastric precancerous lesions.
Keywords: Gastric mucosa, precancerous conditions; Stomach neoplasms, carcinogens; Carcinogenicity test, rats