Abstracts
Copyright ©The Author(s) 2000. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 32-32
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.32
The study of trace elements in the hair of patients with esophageal carcinoma in highrisk area
He-Xi Zhang, Xiu-Ling Li, Wei-Xing Zhao, Xin-Ping Gao, Hua-Min Fu, Yu-Qing Shang
He-Xi Zhang, Department of Hygienic, Xinxiang Medical College, Xinxiang 453003, Henan Province, China
Xiu-Ling Li, Department of Anatomy, Xinxiang Medical College, Xinxiang 453003, Henan Province, China
Wei-Xing Zhao, Xin-Ping Gao, Hua-Min Fu, Department of Pathology, Xinxiang Medical College, Xinxiang 453003, Henan Province, China
Yu-Qing Shang, Department of Foreign Languages, Xinxiang Medical College, Xinxiang 453003, Henan Province, China
Author contributions: All authors contributed equally to the work.
Supported by the Office of Health of Henan Province, No. 199
Correspondence to: Dr. Wei-Xing Zhao, Professor, Department of Hygienics, Department of Pathology, Xinxiang Medical College, Xinxiang 453003, Henan Province, China
Telephone: 373-3029306
Received: January 20, 1999
Revised: June 5, 2000
Accepted: July 10, 2000
Published online: September 15, 2000
Abstract

AIM: To study the change of trace elements in the hair of patients with esophageal carcinoma and the role of trace elements in its development and progress.

METHODS: The hair of 60 normal people and 126 patients was collected and was divided into groups according to the patients’ pathologic changes. The atomic absorption method and fluorescence method were used to measure the trace elements of copper, zinc, iron, calcium and selenium.

RESULTS: Zinc in the hair of various patients: a remarkable difference was found between normal people (182 mg·kg-1) and the patients (103-81.6 mg·kg-1) (t = 3.79, P < 0.01 Duncan’ new multiple range method). There was a certain difference between simple hyperplasia and cancer (t = 3.21, P < 0.01). As for copper, a great difference existed between normal people (12.01 mg·kg-1) and patients with dysphagia (15.16 mg·kg-1) and cancer (17.02-17.15 mg·kg-1) (t = 2.43, P < 0.05). No change of zinc and copper was observed in cancer patients (t = 1.61, P > 0.05). The ratio of zinc to copper increased with the development of pathologic change. The selenium levels in patients (0.46-0.67 mg·kg-1) was below that of normal people (1.03 mg·kg-1), while iron and calcium levels in the patients decreased with the development of pathologic process.

CONCLUSION: Both zinc and copper play an important role in the pathologic change of esophageal carcinoma. Zinc and copper in the hair changed with development of the pathologic process. Zinc revealed positive correlation (r = 0.889, P < 0.01 while copper showed negative correlation (r = 0.921, P < 0.01). The ratio of copper to zinc in the hair is of great diagnostic value.

Keywords: Esophageal neoplasm/etiology; Trace elements; Zinc; copper; Selenium