Real-time ultrasonic observation on the relationship between the cholagogic action of Yin Chen Hao Tang and gallbladder circadian rhythm

doi:10.3748/wjg.v6.iSuppl3.21

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Sep 15, 2000 (publication date) through Nov 8, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 21-21
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.21

Real-time ultrasonic observation on the relationship between the cholagogic action of Yin Chen Hao Tang and gallbladder circadian rhythm

Feng-Zhi Nie, Lan-Feng Dong, Shu-Zhen Di, Lei Nie, Meng-Qi Zhao

Feng-Zhi Nie, Lan-Feng Dong, Shu-Zhen Di, Lei Nie, Department of Pharmacognosy, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China

Meng-Qi Zhao, Department of B-Ultrasonography, Hospital of 3302 Factory, Shijiazhuang 050011, Hebei Province, China

Author contributions: All authors contributed equally to the work.

Supported by Traditional Chinese Medicine Bureau Foundation of Hebei Province, No. 96048

Correspondence to: Dr. Feng-Zhi Nie, Department of Pharmacognosy, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China

Telephone: 311-6064743

Received: November 25, 1999
Revised: April 15, 2000
Accepted: May 10, 2000
Published online: September 15, 2000

Abstract

AIM: To explore gallbladder circadian rhythm (GCR) and the cholagogic action of Yin Chen Hao Tang (YCHT).

METHODS: Ultrasonography of rabbit gallbladder at 17:00 to 19:00, 23:00 to 01:00, 05:00 to 07:00 and 11:00 to 13:00 showed its maximum area (MA), dilatation rate (GDR) and systole rate. Its movement circadian rhythm (MCR) and the effect of YCHT on gallbladder and the relationship with time were observed and evaluated.

RESULTS: The results showed that gallbladder area changed with time, which varied from 11:00 to 13:00 > 23:00 to 01:00 and 05:00 to 07:00 > 17:00 to 19:00 (P < 0.01, F = 9.13 vs control by analysis of variance). The cholagogic action at 23:00 to 01:00 and 17:00 to 19:00 was better than that at 11:00 to 13:00 and 05:00 to 07:00.

CONCLUSION: The gallbladder movement action (GMA) showed markedly circadian rhythm. The cholagogic action of YCHT at 23:00 to 01:00 and 17:00 to 19:00 is better. Traditional Chinese Medicine Bureau Foundation of Hebei Province, No. 96048.

Keywords: Gallbladder/ultrasonography; Circadian rhythm; Cholagogues and choleretics; Yin Chen Hao Tang