Abstracts
Copyright ©The Author(s) 2000. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 140-140
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.140
Microinjection of limonene into caudate nucleus inhibits interdigestive myoelectrical complexe of rats
Hong Guo, Xin-Yi Zhu, Yi-Quan Wei, De-Zhi Yang
Hong Guo, Institute of Physiology, Chinese Academy of Science, Shanghai 200031, China
Xin-Yi Zhu, Yi-Quan Wei, De-Zhi Yang, Medical College, Southeast University, Nanjing 210009, Jiangsu Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. De-Zhi Yang, Professor, Medical College, Southeast University, 87# Dingjiaqiao, Nanjing 210009, Jiangsu Province, China. yang-01@21cn.com
Telephone: 25-3324887 Fax: 25-3317073
Received: May 5, 2000
Revised: June 10, 2000
Accepted: July 10, 2000
Published online: September 15, 2000
Abstract

AIM: We have discovered that Limonene modulates interdigestive myoelectrical complexes (IMCs) of gastrointestinal tract in rats. In this research we will elucidate weather limonene affects acetylcholine M-receptor in caudate nucleus.

METHODS: Changes of IMCs were studied after limonene and/or atropine were microinjected into caudate nucleus. IMCs were recorded by a RM-6200 four-channel recorder and then delivered to Maclab and Power Macintosh.

RESULTS: The active phases of IMCs occupied about 40% of total cycle in average. After microinjection of limonene into caudate nucleus, the active phases were significantly shortened, while the cycle time of IMCs were not changed significantly. The inhibitory effects of limonene were abolished by pretreatment with atropine, whilst the atropine has no effect on IMCs.

CONCLUSION: It is suggested that limonene inhabits the gastrointestinal IMCs by affecting M-receptor in caudate nucleus.

Keywords: Limonene; Interdigestive myoelectrical complexes; Caudate nucleus; Rat