Three-year follow-up study on hepatic fibrosis due to chronic hepatitis B treated by interferon-&alpha;1b and traditional medicine preparation

doi:10.3748/wjg.v6.iSuppl3.139

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Sep 15, 2000 (publication date) through Dec 3, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 139-139
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.139

Three-year follow-up study on hepatic fibrosis due to chronic hepatitis B treated by interferon-α1b and traditional medicine preparation

Ming-Liang Cheng, Yin-Ying Lu, Jun Wu, Tian-Ying Luo, Ke-Fu Huang, Yi-Sheng Ding, Ran-Cai Liu, Jia Li, Zhong Li

Ming-Liang Cheng, Yin-Ying Lu, Jun Wu, Tian-Ying Luo, Ke-Fu Huang, Yi-Sheng Ding, Ran-Cai Liu, Jia Li, Zhong Li, Department of Infectious Diseases, Affiliated Hospital, Guiyang Medical College, Guiyang 550004, Guizhou Province, China

Author contributions: All authors contributed equally to the work.

Supported by The key project of the “9^th Five-Year Plan” of scientific committee of Guizhou Province

Correspondence to: Dr. Ming-Liang Cheng, Professor, Department of Infectious Diseases, Affiliated Hospital, Guiyang Medicine College, Guiyang 550004, Guizhou Province, China. Cheng.ml@21.cn.com

Telephone: 851-5860188 (H), 6828383(O) Fax: 851-6741623

Received: June 24, 2000
Revised: July 1, 2000
Accepted: July 10, 2000
Published online: September 15, 2000

Abstract

AIM: To investigate the short-term and long-term therapeutic effect of traditional medicine preparation and IFN-α1b on hepatic fibrosis due to chronic hepatitis B.

METHODS: Fifty-two patients with hepatic fibrosis of hepatitis B were treated by IFN-α1b and traditional medicine preparation, then observed the change of serum indexes of hepatic fibrosis, liver biopsy, ultrasonography and fibergastroscopy.

RESULTS: The serum indexes of hepatic fibrosis decreased significantly after 3-mo treatment (P < 0.05). The improvement of liver fibrosis was confirmed by liver biopsy, ultrasonography and fibergastroscopy. After 3-year continuous follow-up, the conditions of patients were got better. Symp toms and signs were disappeared. The pathohistologic change of liver, serum index of hepatic fibrosis and liver function were continuously improved.

CONCLUSION: The good short-term and long-term effects were obtained by using IFN-α1b to suppress duplication of hepatitis B virus and traditional medicine preparation to reverse hepatic fibrosis.

Keywords: Hepatitis B; Liver cirrhosis/drug therapy; Interferon-alpha; Drugs, Chinese herbal; Biopsy; Ultrasonography; Follow-up studies