Importance of hepatitis C as a risk factor for hepatocellular carcinoma in Guangxi

doi:10.3748/wjg.v6.iSuppl3.127

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 127-127
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.127

Importance of hepatitis C as a risk factor for hepatocellular carcinoma in Guangxi

Zhuo-Lin Deng, Yun Ma, Ling Yuan, Pin-Kie Teng

Zhuo-Lin Deng, Yun Ma, Ling Yuan, Pin-Kie Teng, Department of Pathology, Guangxi Medical University, Nanning 530021, Guangxi Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Zhuo-Lin Deng, Department of Pathology, Guangxi Medical University, Nanning 530021, China

Telephone: 771-5350477-8262

Received: December 22, 1999
Revised: March 24, 2000
Accepted: May 18, 2000
Published online: September 15, 2000

Abstract

AIM: To examine hepatitis C in hepatocellular carcinoma in most endemic area, Guangxi, China.

METHODS: Immunochemistry was performed on formalin fixed, paraffin embedded tissue sections. A total 202 specimens were analysed from the high, intermediate and low HCC prevalent regions of Guangxi.

RESULTS: The distribution of positive hepatitis C cases from high, intermediate and low regions was respectively 24/63 (38%), 23/62 (37%) and 30/77 (39%), with a total of 77/202 (38.12%).

CONCLUSION: Hepatitis C virus is an important risk factor in the development of hepatocellular carcinoma, but the regional difference in prevalence of this cancer is more likely influenced by hepatitis B viral infection and aflatoxin B1 exposure. In Guangxi, infection of hepatitis B and C virus in the development of hepatocellular carcinoma may be greatly enhanced by exposure to aflatoxin.

Keywords: Hepatitis C; Hepatoma; Risk factor; Immunohistochemistry; Gene, p53; Antibodies, monoclonal; Mutation