Abstracts
Copyright ©The Author(s) 2000. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 120-120
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.120
Clinical and experimental research on weile jiaonang for peptic ulcer
Biao Wu, Pei-Fang Huang, Cai-Li Liu, Wei-He Li
Biao Wu, Cai-Li Liu, Wei-He Li, First Affiliated Hospital, Xinxiang Medical College, Weihui 453100, Henan Province, China
Pei-Fang Huang, Xinxiang Medical College, Weihui 453100, Henan Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Biao Wu, First Affiliated Hospital, Xinxiang Medical College, Weihui 453100, Henan Province, China
Received: April 28, 1999
Revised: January 24, 2000
Accepted: March 18, 2000
Published online: September 15, 2000
Abstract

AIM: To observe the therapeutic effect of weile jiaonang (WLJN) for peptic ulcer (PU) and its toxicity to animals, and to find out the nontoxic Chinese medicines in replacing those chemical medicines with side effect.

METHODS: Five hundred and forty patients with PU were divided into three groups, therapeutic group by WLJN, control group taking famotidine and combined group with WLJN and famotidine. One hundred and eighty patients in each group were studied. The diagnosis of 540 patients with PU is in accordance with the basis provided by the National Scientific Congress of Digestive System Disease convened in Hangzhou, 1978. The study followed the criterion provided by this Congress.

RESULTS: Total effective rate in therapeutic group was 93.3%, and 93.3% in control group. Combined group achieved a total effective rate of 100%. For all three groups, there was no significant difference statistically, but the control group appeared obvious side effects. The result of acute toxic experiments on white mice showed that there no death and toxic side effect even the highest dosage was given, which was equivalant to 120 times to the dosage of patients. The result of chronic toxic experiment showed there was no obvious pathologic change in three dosed groups. The tails of mice in dosed groups were more smooth delicate and cleaner than those in control group.

CONCLUSION: Through observation in clinic and exprimental animal, it is proved that weile jiaonang is particularly effective and safe Chinese patent drug against PU.

Keywords: Peptic ulcer/diagnosis; Peptic ulcer/therapy