Protective effect of Diltiazem on digestive organs in hemorrhagic-shock canine

doi:10.3748/wjg.v6.iSuppl3.109

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Sep 15, 2000 (publication date) through Dec 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 109-109
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.109

Protective effect of Diltiazem on digestive organs in hemorrhagic-shock canine

Zhi-Xiong Xia, Yu-Qin Zhang, Yong-Ming Liu, Lei Wei, Yan-Shu Li, Zhi-Jun Liu

Zhi-Xiong Xia, Yu-Qin Zhang, Yan-Shu Li, Zhi-Jun Liu, Department of Surgery, Medical College, Wuhan University of Science and Technology, Wuhan 430080, Hubei Province, China

Yong-Ming Liu, Lei Wei, Department of Pathophysiology, Hubei Medical University, Wuhan 430077, Hubei Province, China

Author contributions: All authors contributed equally to the work.

Supported by Scientific Research Foundation from Ministry of Metallurgical Industry

Correspondence to: Dr. Zhi-Xiong Xia, Medical College, Wuhan University Science and Technology, Wuhan 430080, Hubei Province, China

Telephone: 27-86322146

Received: May 30, 2000
Revised: June 28, 2000
Accepted: July 10, 2000
Published online: September 15, 2000

Abstract

AIM: To investigate the protective effects and mechanism of Diltiazem (Dil) on liver, pancreas and small intestine in hemorrhagic shock canine.

METHODS: The canines were bled to a mean arterial pressure (MAP) of 5.33-6.67 kPa for 30 min to establish the shock model. During the shock state, the dogs received either water-soluble calcium blocker Dil or saline solution. The MAP was kept at this level for 90 min, then the total blood which was bled previously was reperfused. The total observation time of the experiment was 240 min.

RESULTS: Dil could significantly increase MAP from 150 min to 240 min (P < 0.01) and the activity of superoxide dismutase (SOD) of pancreas tissue (P < 0.01), and it could also decrease the content of malondialdehyde (MDA) in liver, pancreas and small intestine tissues (P < 0.01) and the activity of SOD of the liver and small intestinal tissues (P < 0.01) in the canines. Electron microscopic data indicated that the ultrastructures of liver, pancreas and small intestine tissues were normal in Dil group.

CONCLUSION: Dil can protect the structure and function of the liver, pancreas and small intestinal in hemorrhagic-shock canine.

Keywords: Calcium channel blockers; Diltiazem; Shock, hemorrhagic; Malondialdehyde; Digestive system; Oxygen free radical