Wang YJ, Li MD, Wang YM, Chen GZ, Lu GD, Tan ZX. Effect of extracorporeal bioartificial liver support system on fulminant hepatic failure rabbits. World J Gastroenterol 2000; 6(2): 252-254 [PMID: 11819568 DOI: 10.3748/wjg.v6.i2.252]
Corresponding Author of This Article
Dr. Ying Jie Wang, Center of Infectious Disease, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
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World J Gastroenterol. Apr 15, 2000; 6(2): 252-254 Published online Apr 15, 2000. doi: 10.3748/wjg.v6.i2.252
Effect of extracorporeal bioartificial liver support system on fulminant hepatic failure rabbits
Ying Jie Wang, Meng Dong Li, Yu Ming Wang, Guo Zheng Chen, Guo Dong Lu, Zao Xia Tan
Ying Jie Wang, Meng Dong Li, Yu Ming Wang, Guo Zheng Chen, Guo Dong Lu, Zao Xia Tan Clinical Center of Infectious Disease, Southwest Hospital, Third Military Medical University, Chongqing 400038, China;
Ying Jie Wang, associate professor of the Center of Infections Disease, Southwest Hospital, Third Military Medical University, graduated and obtained a bachelor degree from Yunnan University in 1985, and M.D. from Third Military Medical University in 1997. Specialized in the study of hepatic failure and severe hepatitis, having 70 papers published.
Author contributions: All authors contributed equally to the work.
Supported by the national key project fund of the "9th Five Year Plan", No. 96-920-12-02
Correspondence to: Dr. Ying Jie Wang, Center of Infectious Disease, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
Telephone: 0086-23-68754217
Received: October 12, 1999 Revised: December 6, 1999 Accepted: December 11, 1999 Published online: April 15, 2000
Abstract
AIM: To evaluate the possibility of using cultured human hepatocytes as a bridge between bioartificial liver and liver transplantation.
METHODS: In this experiment, the efficacy of extracorporeal bio artificial liver support system (EBLSS) consisting of spheriodal human liver cells and cultured hepatocytes supernatant was assessed in vivo using galactosamine induced rabbit model of fulminant hepatic failure.
RESULTS: There was no difference of survival between the two groups of rabbits, but in the supported rabbits serum alanine aminotransferase, total bilirubin and creatinine were significantly lower and hepatocyte necrosis was markedly milder than those in control animals. In addition, a good viability of human liver cells was noted after the experiment.
CONCLUSION: EBLSS plays a biologic role in maintaining and compensating the function of the liver.
