Changes of integrin expression in rat hepatocarcinogenesis induced by 3&rsquo;-Me-DAB

doi:10.3748/wjg.v6.i2.231

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Apr 15, 2000 (publication date) through May 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 15, 2000; 6(2): 231-233
Published online Apr 15, 2000. doi: 10.3748/wjg.v6.i2.231

Changes of integrin expression in rat hepatocarcinogenesis induced by 3’-Me-DAB

Sheng Tao Yuan, Xi Qi Hu, Jian Ping Lu, Hayashi KeiKi, Wei Rong Zhai, Yue E Zhang

Sheng Tao Yuan, Xi Qi Hu, Jian Ping Lu, Wei Rong Zhai, Yue E Zhang, Department of Pathology, Shanghai Medical University, Shanghai 200032, China;

Hayashi KeiKi, Department of Pathology, Okayama University, Japan;

Sheng Tao Yuan, got a master degree in 1996 in Shanghai Medical University and now is working in Shanghai Institute of Materia Medica, Chinese Academy of Sciences.

Author contributions: All authors contributed equally to the work.

Correspondence to: Sheng Tao Yuan, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China

Telephone: 0086-21-64311833 Ext.505

Received: November 29, 1999
Revised: December 16, 1999
Accepted: December 29, 1999
Published online: April 15, 2000

Abstract

AIM: To investigate the expression of integrins in rats liver during 3'-Me-DAB induced hepatocarcinogenesis and to find out the relationship between integrins and liver cancer metastasis.

METHODS: The expressions of integrins α₁, α₂, α₃ and α₅ and epidermal keratin (EK) were observed by immunohistochemical PAP method.

RESULTS: In the normal liver tissues, hepatocytes express integrins α₁ and α₅ and in the bile duct epithlium, EK. In liver cirrhosis, hepatocytes highly express integrins α₁, α₂, α₃ and α₅ and in hyperplastic bile duct epithelium, integrins α₁, α₅ and EK. Expression of integrins α₁, α₂, α₃ and α₅ were obviously decreased in the preneoplastic nodules and primary carcinoma but expressions of integrins α₁ and α₅ in metastasis in the lung and diaphragma were higher than those in primary carcinoma.

CONCLUSION: Integrins α₁ and α₅ may play a major role in chemically induced hepatocarcinogenesis and metastasis in rats.

Keywords: integrins, 3’Me-DAB, liver neoplasm/chemically induced, neoplasm metastasis, rats