Original Articles
Copyright ©The Author(s) 2000. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 15, 2000; 6(2): 231-233
Published online Apr 15, 2000. doi: 10.3748/wjg.v6.i2.231
Changes of integrin expression in rat hepatocarcinogenesis induced by 3’-Me-DAB
Sheng Tao Yuan, Xi Qi Hu, Jian Ping Lu, Hayashi KeiKi, Wei Rong Zhai, Yue E Zhang
Sheng Tao Yuan, Xi Qi Hu, Jian Ping Lu, Wei Rong Zhai, Yue E Zhang, Department of Pathology, Shanghai Medical University, Shanghai 200032, China;
Hayashi KeiKi, Department of Pathology, Okayama University, Japan;
Sheng Tao Yuan, got a master degree in 1996 in Shanghai Medical University and now is working in Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
Author contributions: All authors contributed equally to the work.
Correspondence to: Sheng Tao Yuan, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, China
Telephone: 0086-21-64311833 Ext.505
Received: November 29, 1999
Revised: December 16, 1999
Accepted: December 29, 1999
Published online: April 15, 2000
Abstract

AIM: To investigate the expression of integrins in rats liver during 3'-Me-DAB induced hepatocarcinogenesis and to find out the relationship between integrins and liver cancer metastasis.

METHODS: The expressions of integrins α1, α2, α3 and α5 and epidermal keratin (EK) were observed by immunohistochemical PAP method.

RESULTS: In the normal liver tissues, hepatocytes express integrins α1 and α5 and in the bile duct epithlium, EK. In liver cirrhosis, hepatocytes highly express integrins α1, α2, α3 and α5 and in hyperplastic bile duct epithelium, integrins α1, α5 and EK. Expression of integrins α1, α2, α3 and α5 were obviously decreased in the preneoplastic nodules and primary carcinoma but expressions of integrins α1 and α5 in metastasis in the lung and diaphragma were higher than those in primary carcinoma.

CONCLUSION: Integrins α1 and α5 may play a major role in chemically induced hepatocarcinogenesis and metastasis in rats.

Keywords: integrins; 3’Me-DAB; liver neoplasm/chemically induced; neoplasm metastasis; rats