Bian JC, Shen FM, Shen L, Wang TR, Wang XH, Chen GC, Wang JB. Susceptibility to hepatocellular carcinoma associated with null genotypes of GSTM1 and GSTT1. World J Gastroenterol 2000; 6(2): 228-230 [PMID: 11819562 DOI: 10.3748/wjg.v6.i2.228]
Corresponding Author of This Article
Dr. Jian Chao Bian, Department of Epidemiology, Shanghai Medical University, 138 Yixueyuan Road, Shanghai 200032, China. Email: jcbian@shmu.edu.cn http:www.shmu.edu.cn
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World J Gastroenterol. Apr 15, 2000; 6(2): 228-230 Published online Apr 15, 2000. doi: 10.3748/wjg.v6.i2.228
Susceptibility to hepatocellular carcinoma associated with null genotypes of GSTM1 and GSTT1
Jian Chao Bian, Fu Min Shen, Li Shen, Tian Ru Wang, Xiao Hong Wang, Gong Chao Chen, Jin Bing Wang
Jian Chao Bian, Fu Min Shen, Li Shen, Tian Ru Wang, Xiao Hong Wang, Department of Epidemiology, Shanghai Medical University, Shanghai 200032, China;
Gong Chao Chen, Haimen Municipal Anti-Epidemic and Health Station, Haimen 226201, Jiangsu Province, China;
Jin Bing Wang, Qidong Institute for Liver Cancer, Qidong 226200, Jiangsu Province, China;
Jian Chao Bian, graduated from Henan Medical University as a Bachelor of Medicine in 1984, graduated from Xi′an Medical University as a Master of Medicine in 1990, and from Shanghai Medical University as a Doctor of Medicine in 1995, now associate professor of epidemiology, majoring molecular and genetic epidemiology of hepatocellular carcinoma, having 22 papers published.
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No. 39470628 and the Scientific Foundation of Ministry of Health, China, No. 96-1-189
Correspondence to: Dr. Jian Chao Bian, Department of Epidemiology, Shanghai Medical University, 138 Yixueyuan Road, Shanghai 200032, China. Email: jcbian@shmu.edu.cn http:www.shmu.edu.cn
Received: July 3, 1999 Revised: August 26, 1999 Accepted: September 5, 1999 Published online: April 15, 2000
Abstract
AIM: In order to study the association between the null genotypes of GSTM1 and GSTT1 and the genetic susceptibility to hepatocellular carcinoma (HCC).
METHODS: The genotypes of GSTM1 and GSTT1 of 63 cases of HCC and 88 controls were detected with the multiple PCR technique.
RESULTS: The frequency of GSTM1 null genotype was 57.1% among the cases, and 42.0% among the controls, the difference being statistically significant (χ² = 3.35, P = 0.067), but χ² value approaching the significance level. The odds ratio was 1.84 (95%CI = 0.91-3.37). The frequency of GSTT1 non-null genotype was 87.3% among the cases and 62.5% among the controls, the difference being statistically significant (χ² = 11.42, P = 0.0007274). The oddsn ratio was 4.13 (95%CI = 1.64-10.70). According to the cross analysis, the GSTT1 non-null genotype was more closely associated with HCC than GSTM1 null genotype, and these two factors play an approximate additive interaction in the occurrence of HCC.
CONCLUSION: The persons with GSTM1 null genotype and GSTT1 non-null genotype have the increased risk to HCC.
