Gene expression of hepatocyte growth factor and its receptor in HCC and nontumorous liver tissues

doi:10.3748/wjg.v5.i2.119

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Apr 15, 1999 (publication date) through May 6, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 15, 1999; 5(2): 119-121
Published online Apr 15, 1999. doi: 10.3748/wjg.v5.i2.119

Gene expression of hepatocyte growth factor and its receptor in HCC and nontumorous liver tissues

Yun-Quan Luo, Meng-Chao Wu, Wen-Ming Cong

Yun-Quan Luo, Meng-Chao Wu, Wen-Ming Cong, Eastern Hospital of Hepatobiliary Surgery, Second Military Medical Unive rsity, Shanghai 200438, China

Yun-Quan Luo, male, born on 1963-10-10 in Huoqiu County, Anhui Province, Han nationality, graduated from Second Military Medical University as a doctor postgraduate in 1995, associate professor of hepatobiliary surgery, majoring hepatobiliary surgery, having 25 papers published.

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Yun-Quan Luo, Eastern Hospital of Hepatobiliary Surgery, Second Military Medical University, Shanghai 200438, China. yqluo@guomai.sh.cn

Telephone: +86-21-25070844

Received: November 20, 1998
Revised: January 2, 1999
Accepted: January 20, 1999
Published online: April 15, 1999

Abstract

AIM To study the changes of gene expression of hepatocyte growth factor (HGF) and hepatocyte growth factor receptor (HGFr) in hepatocellular carcinoma (HCC) tissue and nontumorous liver tissue and the relationship between these changes and the biological behavior of the tumor.

METHODS Gene expression of HGF and HGFr in 26 cases of HCC tissue and their adjacent nontumorous liver tissues was determined with digoxigenin-labeled DNA probes.

RESULTS Positive expression of HGF in HCC tissue was similar to that in the adjacent nontumorous liver tissue, but positive rate of HGF expression was lower than HGFr gene expression. However, HGFr expression was higher in the metastatic cases than in those without metastasis. It was found that HGFr was overexpressed in HCC tissue as well as in the adjacent nontumorous liver tissue.

CONCLUSION There seems to be a close relationship between overexpression of HGFr gene and tumor metastasis, and the HGF and HGFr system pla ys an important role in regulating tumor growth and metastasis.

Keywords: liver neoplasm, hepatocyte growth factor receptor, hepatocyte growth factor, gene expression