Original Articles
Copyright ©The Author(s) 1999. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 15, 1999; 5(1): 31-33
Published online Feb 15, 1999. doi: 10.3748/wjg.v5.i1.31
Multifactorial analysis of recurrence of cholecystolithiasis in Shanghai area
Pei Chen, Bing-Sheng Wang, Lian-Qi He
Pei Chen, Bing-Sheng Wang, Lian-Qi He, Department of General Surgery, Zhongshan Hospital, Shanghai Medical University, Shanghai 200032, China
Pei Chen, male, born on 1970-08-04 in Shanghai, now a doctor-al student in Shanghai Medical University, majoring in biliary tract surgery, worki ng in the Department of General Surgery, Zhongshan Hospital, Shanghai 200032, China.
Author contributions: All authors contributed equally to the work.
Supported by the scientific research fund of Shanghai Committee of Science and Technology.
Correspondence to: Professor Bing-Sheng Wang, Department of General Surgery, Zhongshan Hospital, Shanghai Medical University, Shanghai 200032, China
Telephone: +86-21-64041990 Ext. 2912, 2302
Received: October 4, 1998
Revised: November 20, 1998
Accepted: December 12, 1998
Published online: February 15, 1999
Abstract

AIM: To explore the risk factors of gallbladder stone recurrence.

METHODS: A multifactorial analysis was made for 1058 patients in Shanghai area whose gall-bladder stones disappeared after different kinds of nonsurgical therapy, including oral litholytic therapy, extracorporeal shock wave lithotripsy and percutaneous choledocholithotripsy. Serum level of in sulin and total bile acid were deter-mined in 122 patients.

RESULTS: After 1-8.8 years of follow-up, the re-currence rate of gallbladder stone was 11.6%, 22.4%, 29.5%, 36.4%, 39.3% and 39.7% re-spectively within 1, 2, 3, 4, 5 and over 5 years. The risk factors for the recurrence are: primary multiple gallstones (P < 0.05); family history of cholecysto lithiasis (P < 0.05); greasy food in-take (P < 0.01); low mean value of serum insulin (P < 0.01); and high mean value of total bile acid (P < 0.01).

CONCLUSION: The recurrence of cholecys-tolithiasis is related to overintake of high fat and high cholesterol food, and might also be related to low level of serum insulin.

Keywords: cholecystolithiasis/ therapy; recurrence; follow-up studies