Xu MY, Lu HM, Wang SZ, Shi WY, Wang XC, Yang DX, Yang CX, Yang LZ. Effect of devazepide reversed antagonism of CCK-8 against morphine on electrical and mechanical activities of rat duodenum in vitro. World J Gastroenterol 1998; 4(6): 524-526 [PMID: 11819361 DOI: 10.3748/wjg.v4.i6.524]
Corresponding Author of This Article
Prof. Man-Ying Xu, Department of Physiology, Harbin Medical University, Harbin 150086, Heilongjiang Province, China.
Article-Type of This Article
Original Articles
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Man-Ying Xu, Hui-Ming Lu, Shu-Zhen Wang, Department of Physiology, Harbin Medical University, Harbin 150086, China
Wen-Yan Shi, Xin-Chun Wang, Department of Scientific Research, Harbin Medical University, Harbin 150086, China
Dong-Xiao Yang, Chun-Xiao Yang, Li-Zhuang Yang, Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China
Man-Ying Xu, female, born on May 22, 1943 in Harbin City, Heilongjiang Province, Han nationality, graduated from Harbin Medical University in 1968, now professor of physiology, majoring mechanisms of morphine analgesia and antagonism to morphine analgesia, having more than 60 papers published.
Author contributions: All authors contributed equally to the work.
Correspondence to: Prof. Man-Ying Xu, Department of Physiology, Harbin Medical University, Harbin 150086, Heilongjiang Province, China.
Telephone: +86-451-6667498
Received: July 6, 1998 Revised: September 20, 1998 Accepted: November 14, 1998 Published online: December 15, 1998
Abstract
AIM: To study the antagonism of cholecystokinin octapeptide (CCK-8) against the effect of morphine and its mechanism.
METHODS: The method and mechanical activities of rat duodenum in vitro were recorded simultaneously.
RESULTS: Acetylcholine (ACh) could increase the amplitude and the number of the spike potential (SPA and SPN) of rat duodenum in vitro, followed by the increase of the duodenal contraction amplitudes (CA), showing a positive correlation. Morphine, on the contrary, inhibited the potentiation of ACh, showing a negative correlation. CCK-8 could antagonize the effects of morphine, i.e. the SPA and SPN were increased again, followed by the increase of CA. CCK-A receptor antagonist Devazepide could reverse the antagonism of CCK-8 to the effect of morphine.
CONCLUSION: CCK-8 could antagonize the effect of morphine which inhibited the potentiation of ACh on the duodenal activities in vitro. The antagonistic effect of CCK-8 on morphine was mainly mediated by CCK-A receptor.
