Zhao GQ, Xue L, Xu HY, Tang XM, Hu RD, Dong J. In situ hybridization assay of androgen receptor gene in hepatocarcinogenesis. World J Gastroenterol 1998; 4(6): 503-505 [PMID: 11819355 DOI: 10.3748/wjg.v4.i6.503]
Corresponding Author of This Article
Dr. Guo-Qiang Zhao, Department of Pathology, Sun Yat-Sen University of Medical Sciences, 74 Zhongshan 2nd Rd., Guangzhou 510089, Guangdong Province, China. zhaogq@gzsums.edu.cn
Article-Type of This Article
Original Articles
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Guo-Qiang Zhao, Ling Xue, Hong-Yu Xu, Xi-Ming Tang, Rui-De Hu, Jun Dong, Department of Pathology, Sun Yat-Sen University of Medical Sciences, Guangzhou 510089, Guangdong Province, China
Guo-Qiang Zhao, Ph.D., male, born on 1956-12-19 in Zhengzhou City, Henan Province, graduated from Henan Normal University in 1982, got Ph.D. in Philipps-University of Marburg, Germany in 1992, now associate professor of molecular pathology, majoring molecular mechanism of hepatocarcinogenesis, having 7 papers published.
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Guo-Qiang Zhao, Department of Pathology, Sun Yat-Sen University of Medical Sciences, 74 Zhongshan 2nd Rd., Guangzhou 510089, Guangdong Province, China. zhaogq@gzsums.edu.cn
Telephone: +86-20-87331784 Fax: +86-20-87331679
Received: August 21, 1998 Revised: October 20, 1998 Accepted: November 21, 1998 Published online: December 15, 1998
Abstract
AIM: To determine the correlation between expression of androgen receptor (AR) gene and hepatocarcinogenesis.
METHODS: Male SD rats were used as experimental animals and the animal model of experimental hepatocarcinoma was established by means of 3’-me-DAB administration. Androgen receptor mRNA was detected by a non-radioactive in situ hybridization assay in neoplastic and non-neoplastic liver tissues.
RESULTS: The expression of androgen receptor mRNA was observed only in neoplasticcells and some atypical hyperplastic cells. In the liver tissue of control animal and the remaining normal liver cells adjacent to the carcinoma tissue, no positive signal was seen.
CONCLUSION: Androgen has an important correlation with hepatocarcinogenesis and the expression of androgen receptor gene might be a mark event during hepatocarcinogenesis.
