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©The Author(s) 1998. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 15, 1998; 4(5): 418-420
Published online Oct 15, 1998. doi: 10.3748/wjg.v4.i5.418
Published online Oct 15, 1998. doi: 10.3748/wjg.v4.i5.418
Interaction between cisplatin, 5-fluorouracil and vincristine on human hepatoma cell line (7721)
Wei-Xue Tang, Ping-Yan Cheng, Yun-Peng Luo, Rui-Xue Wang, Department of Pathophsiology, Chongqing University of Medical Sciences, Chongqing 400046, China
Wei-Xue Tang, female, born on 1945-01-29 in Shanghai, graduated from Shanghai Second Medical University in 1968, associate professor of pathophysiology in Chongqing Medical University, engaged in the research of anticancer drug sensitivity test, having 10 papers published.
Author contributions: All authors contributed equally to the work.
Correspondence to: Wei-Xue Tang, Department of Pathophysiology, Chongqing University of Medical Sciences, Chongqing 400046, China
Telephone: +86-23-68807688
Received: May 25, 1998
Revised: June 29, 1998
Accepted: August 14, 1998
Published online: October 15, 1998
Revised: June 29, 1998
Accepted: August 14, 1998
Published online: October 15, 1998
Abstract
AIM: To evaluate the killing effects of CDDP, 5-Fu and VCR on human hepaoma cell line (7721).
METHODS: The median-effect principle was used.
RESULTS: Killing effects of the individual drug were enhanced as the median concentration increased. Antagonism was produced when two drugs were used at a higher concentration (CI > 1), and synergism was achiened when CI < 1. Finally, the effect was influenced by both the ratios of drug concentration and the sequence of administration.
CONCLUSION: The drug administration order and drug concentrations are significant factors that need to be considered in clinical practice.
Keywords: liver neoplasms; cisplatin; 5-fluorouracil; vincristine; cell line