Combined Traditional and Modern Medicine
Copyright ©The Author(s) 1998. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 15, 1998; 4(3): 256-259
Published online Jun 15, 1998. doi: 10.3748/wjg.v4.i3.256
Protective effect of YHI and HHI-I against experimental acute pancreatitis in rabbits
Lian-Gen Zhao, Xiao-Xian Wu, En-Kun Han, Yu-Ling Chen, Chi Chen, Dong-Qin Xu
Lian-Gen Zhao, Xiao-Xian Wu, En-Kun Han, Yu-Ling Chen, Chi Chen, Dong-Qin Xu, Research Laboratory of Pathophysiology, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin 300100, China
Lian-Gen Zhao, male, born on 1938-07-02 in Tangshan, Hebei Province, graduated from Pathophysiology Department, Beijing Medical College, research fellow, Director of Pathophysiology Research Laboratory, majoring experimental research of acute pancreatitis and TCM Huoxuehuayu therapeutic principle, having 44 papers published.
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Lian-Gen Zhao, Research Laboratory of Pathophysiology, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin 300100, China
Telephone: +86-22-27370021
Received: December 30, 1997
Revised: March 20, 1998
Accepted: May 10, 1998
Published online: June 15, 1998
Abstract

AIM: To observe the protective effect of combined i.v. administraction of Yuanhu injection (YHI) and Huoxuehuayu injection-I (HHI-I) against acute pancreatitis (AP) in rabbits.

METHODS: Sever acute pancreatitis (SAP) was induced by retrograde infusion of artificial bile juice into biliary-pancreatic duct, and treated with YHI and HHI-I intravenously. The protective effect was judged by the survival time and rate, serum amylase, serum interleukin-6, pancreatic microcirculation and pathological alteration.

RESULTS: Combined use of YHI and HHI-I could markedly increase the rabbits’ 5-d survival rate after AP (83.3% in the treatment group and 33.3% in control). The serum amylase value (x-±s) decreased to 1596.6 U/L ± 760.50 U/L in the 5th day from the high level (6320.83 U/L ± 2614.12 U/L) in the 1st day after AP in the treatment group, while in the control group the amylase activity in the 5th day was 2095.0 U/L ± 1081.87 U/L, being significantly different from that before AP (837.17 U/L ± 189.12 U/L). YHI and HHI-I also obviously improved the pancreatic microcirculation and lowered the serum interleukin-6 level, one of the indices of severe pancreatitis. Pathological examination indicated all the changes typical for AP in YHI and HHI-I treatment group were milder than those in the control.

CONCLUSION: YHI and HHI-I used in combination might have protective effect against acute pancreatitis in rabbits.

Keywords: pancreatitis/pathology; pancreatitis/therapy; Yuanhu; Huoxuehuayu; amylase/blood; interleukin-6/blood; microcirculation; rabbits