Peripheral mechanism of inhibitory effect of centrally administrated histamine on gastric acid secretion

doi:10.3748/wjg.v4.i3.222

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Jun 15, 1998 (publication date) through Apr 29, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 15, 1998; 4(3): 222-224
Published online Jun 15, 1998. doi: 10.3748/wjg.v4.i3.222

Peripheral mechanism of inhibitory effect of centrally administrated histamine on gastric acid secretion

Zhi-Fang Zhang, Zhu-Li Wang, Guang-Qi Lu

Zhi-Fang Zhang, Zhu-Li Wang, Guang-Qi Lu, Department of Physiology, Sun Yat-Sen University of Medical Sciences, Guangzhou 510089, Guangdong Province, China

Zhi-Fang Zhang, male, born on 1964-10-14 in Pingdingshan City, Henan Province, graduated from Henan Medical University as a postgraduate in 1991, now a lecturer of physiology majoring gastrointestinal physiology, having 5 papers published.

Author contributions: All authors contributed equally to the work.

Correspondence to: Zhi-Fang Zhang, Department of Physiology, Sun Yat-Sen University of Medical Sciences, Guangzhou 510089, Guangdong Province, China

Telephone: +86-20-87778223 ext 3274 Fax: +86-20-87765679

Received: January 31, 1998
Revised: April 2, 1998
Accepted: May 16, 1998
Published online: June 15, 1998

Abstract

AIM: To study the peripheral mechanism of the inhibitory effect of intra-third ventricular administration (icv) of histamine (HA) on gastric acid secretion in rats.

METHODS: Gastric acid was continuously washed with 37 °C saline by a perfusion pump in male adrenalectomized SD rats. Drugs were injected intravenously (iv) by a syringe pump and their effect on pentagastrin-induced (10 μg·kg·h, iv) gastric acid secretion was observed.

RESULTS: The inhibitory effect of HA (1 μg, icv) on gastric acid secretion was blocked by subdiaphragmatic vagotomy, and pretreatment with atropine (0.005 mg·kg·h, iv). Pretreatment with somatostatin antagonist, cyclo-[7-aminoheptanoyl-Phe-D-Trp-Lys-Thr(Bzl)], (2 μg-4 μg·kg·100 min, iv) could also block the inhibitory effect of HA on gastric acid secretion in a dose dependent manner.

CONCLUSION: The inhibitory effect of centrally administrated HA on gastric acid secretion may be mediated by vagi, acetylcholine M receptor and somatostatin.

Keywords: gastric acid/secretion, histamine, stomach/physiology, somatostatin, acetylcholine M ceceptor, rats