Zhu HM, Huang X, Deng CZ, Porro GP, Pace F, Sangaletti O. Pathogenetic factors affecting gastroesophageal reflux in patients with esophagitis and concomitant duodenal ulcer: a multivariate analysis. World J Gastroenterol 1998; 4(2): 153-157 [PMID: 11819262 DOI: 10.3748/wjg.v4.i2.153]
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Dr. Hui-Ming Zhu, Department of Gastroenterology, 2nd Affiliated Hospital, Medical College of Jinan University, No.3, Dongmen Beilu, Shenzhen 518001, Guangdong Province, China
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World J Gastroenterol. Apr 15, 1998; 4(2): 153-157 Published online Apr 15, 1998. doi: 10.3748/wjg.v4.i2.153
Pathogenetic factors affecting gastroesophageal reflux in patients with esophagitis and concomitant duodenal ulcer: a multivariate analysis
Hui-Ming Zhu, Xun Huang, Chuang-Zheng Deng, G. Pianchi Porro, F. Pace, O. Sangaletti
Hui-Ming Zhu, Xun Huang, Chuang-Zheng Deng, Department of Gastroenterology, 2nd Affiliated Hospital, Medical College of Jinan University, No.3, Dongmen Beilu, Shenzhen 518001, Guangdong Province, China
G. Pianchi Porro, F. Pace, O. Sangaletti, Division of Gastroenterology, Milan University Hospital, Italy
Hui-Ming Zhu, male, born on 1951-11-04 in Wuhan City, Hubei Province, graduated from Tongji Medical University as an M.D. in 1987 and worked for postdoctoral research in Milan University of Italy during 1988-1992, having 56 papers published.
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Hui-Ming Zhu, Department of Gastroenterology, 2nd Affiliated Hospital, Medical College of Jinan University, No.3, Dongmen Beilu, Shenzhen 518001, Guangdong Province, China
Telephone: +86·755·5533018 ext 2551
Received: November 20, 1997 Revised: January 20, 1998 Accepted: March 2, 1998 Published online: April 15, 1998
Abstract
AIM: To assess the relationship between gastric acid output (GAO) and both pattern of gastroesophageal reflux (GER) and esophageal lesions, and to evaluate the role of GAO and other potential pathogenetic factors in the development of esophagitis.
METHODS: Gastric acid secretory testing and 24-h intraesophageal pH monitoring were performed in 31 patients with esophagitis and concomitant duodenal ulcer (E + DU) and compared with those of 72 patients with esophagitis (E) alone.
RESULTS: The GAO in patients with E + DU was significantly higher than in patients with E (P < 0.05). There was no significant difference between the two groups of patients as to endoscopicl findings and parameters of GER (P > 0.05). A multiple regression analysis with stepwise deletion showed that the presence of hiatal hernia (HH), GER in upright position and age appeared to correlate significantly with the presence of esophagitis.
CONCLUSIONS: No parallel relationship between GAO and severity of GER or esophageal lesions exists in patients with E + DU, and that GAO is not a major pathogenetic factor in GER disease.
