Li L, Yan LN, Chen XL, Lu WS, Xie XD, Wu YT. Hepatic adenylate energy charge levels in patients with hepatoma after hepatic artery embolization. World J Gastroenterol 1998; 4(2): 109-111 [PMID: 11819250 DOI: 10.3748/wjg.v4.i2.109]
Corresponding Author of This Article
Dr. Li Li, Department of General Surgery, The First Affiliated Hospital, West China University of Medical Sciences, 37 Wainan Guoxuexiang, Chengdu 610041, Sichuan Province, China
Article-Type of This Article
Original Articles
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Li Li, Lu-Nan Yan, Xiao-Li Chen, Yan-Tao Wu, Department of General Surgery, The First Affiliated Hospital, West China University of Medical Sciences, 37-Wainan Guoxuexiang, Chengdu 610041, Sichuan Province, China
Wu-Sheng Lu, Xiao-Dong Xie, Department of Radiology, The First Affiliated Hospital, West China University of Medical Sciences, 37-Wainan Guoxuexiang, Chengdu 610041, Sichuan Province, China
Li Li, male, born on 1963-01-16 in Chongqing, graduated from West China University of Medical Sciences in 1997 master, surgeon-in-charge, engaged in clinical and experimental study on gastroenterology, having 15 papers published.
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Li Li, Department of General Surgery, The First Affiliated Hospital, West China University of Medical Sciences, 37 Wainan Guoxuexiang, Chengdu 610041, Sichuan Province, China
Received: October 28, 1997 Revised: December 15, 1997 Accepted: January 10, 1998 Published online: April 15, 1998
Abstract
AIM: To evaluate hepatic energy charge levels of the patients with hepatoma after hepatic artery embolization and its relation to postoperative complications.
METHODS: Sixty-nine patients with hepatoma were continuously measured for their arterial blood ketone body ratio (AKBR) and compared with their postoperative clinical course or conventional liver function test after various hepatic artery embolization.
RESULTS: AKBR in high radiation dose or jaundice group drastically decreased at 1-3 d and recovered slowly. Patients were classified into three groups according to the value of AKBR: group A (35 cases), AKBR remained higher than 0.7; group B (31 cases), AKBR had transiently dropped to 0.4-0.7 and then increased to preoperative value; and group C (3 cases), AKBR decreased steadily to below 0.4. The occurrence rate of various complications were 5.7%, 32.3% and 100% in the three groups, respectively (P < 0.005).
CONCLUSION: The AKBR which reflects hepatic mitochondria redox state is morereliable as a direct indicator to assess hepatic tolerance for embolization than routine liver function test.
