Published online Apr 7, 2025. doi: 10.3748/wjg.v31.i13.104046
Revised: February 21, 2025
Accepted: March 10, 2025
Published online: April 7, 2025
Processing time: 114 Days and 2.2 Hours
Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of fat in the liver in individuals who do not consume alcohol. Several risk factors influencing the onset of NAFLD after laparoscopic pancreaticoduodenectomy (LPD) have been identified. This study investigated the risk factors associated with the development of fatty liver after laparoscopic duodenum-preserving pancreatic total head resection (LDPPHRt) and LPD.
To compare the effects of LDPPHRt and LPD on the development of postope
This retrospective cohort study included 59 patients who were histologically diagnosed with benign or low-grade malignant pancreatic tumors and who un
Of the 59 patients included in the study, 17 (28.8%) developed NAFLD within 6-12 months post-surgery. The incidence of NAFLD was significantly higher in the LPD group compared to the LDPPHRt group (40.0% vs 12.5%, P = 0.022). Multivariable analysis identified the LDPPHRt surgical approach (compared to LPD) as an independent protective factor against the development of postoperative NAFLD, with an odds ratio of 0.208 (95% confidence interval: 0.046-0.931; P = 0.040).
Our findings indicate that LDPPHRt is more effective than LPD in reducing the incidence of postoperative NAFLD, which may inform surgical decision-making and optimize patient outcomes after laparoscopic pancreatic surgery.
Core Tip: Our study demonstrates that laparoscopic pancreatic total head resection with preservation of the duodenum is more effective than laparoscopic pancreatic head duodenectomy in preventing postoperative nonalcoholic fatty liver disease. In addition, we identified the factors associated with the development of fatty liver after pancreatic surgery.